Scientific Publications

2021

Lorenzoni, R.; Contri, R.V.; Lima, C. K. F.; Barreto, F. ; Araujo, B. V.; Pohlmann, A.R. ;  Miranda, A.L.P. ; Costa, T.D. ; Guterres, S.S . Dermatopharmacokinetic and pharmacodynamic evaluation of a novel nanostructured formulation containing capsaicinoids for treating neuropathic pain. International Journal of Pharmaceutics, v. 596, p. 120294, 2021.

Doi: 10.1016/j.ijpharm.2021.120294


Robba, C.; Battaglini, D. ; Ball, L.; Valbusa, A. ; Porto, I. ; Bona, R.D.; Malfa, G. ; Patroniti, N. ; Brunetti, I. ; Loconte, M. ; Bassetti, M. ; Giacobbe, D. R. ; Vena, Antonio ; Silva, C.L. M. ; Rocco, P. R. M. ; Pelosi, P.  Coagulative Disorders in Critically Ill COVID-19 Patients with Acute Distress Respiratory Syndrome: A Critical Review. Journal of Clinical Medicine, v. 10, p. 140, 2021.

 

Doi: 10.3390/jcm10010140

Santana, M. V. S. ; Silva, F. P. . De novo design and bioactivity prediction of SARS-CoV-2 main protease inhibitors using recurrent neural network-based transfer learning. BMC Chemistry, v. 15, p. 8, 2021.

Doi:10.1186/s13065-021-00737-2

Silva, J. S. ; Montagnoli, T. L. ; Rocha, B. S. ; Tacco, M. L. C. A. ; Marinho, S. C. P. ;  Sudo, G.Z . Estrogen Receptors: Therapeutic Perspectives for the Treatment of Cardiac Dysfunction after Myocardial Infarction. International Journal of Molecular Sciences, v. 22, p. 525, 2021.

 

Doi:10.3390/ijms22020525

Alencar, A. K.N. ; Wang, H. ; Oliveira, G. M.M. ; Sun, X. ;  Sudo, G.Z. ; Groban, L. Crossroads between Estrogen Loss, Obesity, and Heart Failure with Preserved Ejection Fraction.. Arquivos Brasileiros de Cardiologia (eletronic), v. 00, p. 1, 2021.

 

Silva, J. ; Thompson'souza, G. A. ; Barroso, Marina Valente ; Neves, J. S. ; Figueiredo, R. T. Neutrophil and eosinophil DNA extracellular trap formation: lessons from pathogenic fungi. Frontiers in Microbiology, 2021.

 

Doi: 10.3389/fmicb.2021.634043

Barroso, M.V. ; Gropillo, I. ; Detoni, M. ; Thompson'souza, G. A. ; Vasconcelos, C. I. ; Muniz, V. S. ; Figueiredo, R. T. ; Melo, R. C N ; Neves, J. S.Signaling events driving Aspergillus fumigatus-induced human eosinophils extracellular trap release. Frontiers in Microbiology, 2021.

 

Couto, J.; Simas, D. ; Silva, M. ; Barth, T. ; Pinto, S.; Tinoco, L.W. ; Freire, D.; Muzitano, M. ; Leal, I.. HSCCC Separations of Rutin Esters Obtained by Enzymatic Reaction Catalyzed by Lipase. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY , v. 000, p. 000, 2021.

 

Doi: 10.21577/0103-5053.20200206 


Silveira, F. F.; Souza, J. O.; Hoelz, L. V.B. ; Campos, V. R. ; Jabor, V. A.P. ; Aguiar, A. C.C. ; Nonato, M. C. ; Albuquerque, M. G. ; Guido, R. V.C. ; Boechat, N. ; Pinheiro, L.C.S.  Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors. European Journal of Medicinal Chemistry, v. 209, p. 112941, 2021.

 

 

Doi:10.1016/j.ejmech.2020.112941

Dias, F.; Guerra, F.; Lima, F. ; Castro, Y. ; Ferreira, V. ; Campos, V. ; Fernandes, P. ; Cunha, A. Synthesis and Biological Evaluation of Benzo[f]indole-4,9-diones N-Linked to Carbohydrate Chains as New Type of Antitumor Agents. Journal of the Brazilian Chemical Society, v. 1, p. 1-14, 2021.

 

Doi.org/10.21577/0103-5053.20200202.

Carvalho, P.R.; Sirois, P.; Fernandes, P.D.  The role of kallikrein-kinin and renin-angiotensin systems in COVID-19 infection. Peptides, v. 135, p. 170428, 2021.

 

Doi.org/10.1016/j.peptides.2020.170428

Junior, A.T.F.; Anjos, F.F.; Brito, F. C. M. ; Viana, V.G.F. ; Valença, S.S. ; Lanzetti, M. ; Finotelli, P.V. Bixin loaded on polymeric nanoparticles: synthesis, characterization, and antioxidant applications in a biological system. Applied Nanoscience, v. 11, p. 63-78, 2021.

 

Doi: 10.1007/s13204-020-01555-z

2020

Silva, N. L. C.; Mota, N. A. V. ; Soares, M. A. ; Araujo, O.M.O.; Espindola, L. C. P. ; Colombo, A. P. V. ; Lopes, R. T. ; Brito, F.C. F. ; Miranda, A. L. P. ; Tributino, J.L.M . Periodontal status, vascular reactivity, and platelet aggregation changes in rats submittedto hypercholesterolemic diet and periodontitis. Journal of periodontal research, v. 55, p. 453-463, 2020.

 

Doi: 10.1111/jre.12730

 

 

Rodrigues, D. A.; Pinheiro, P.S.M. ; Sagrillo, F.S. ; Freitas, M.C.R. ; Alves, M.A, ; Thota, S. ; Tinoco, L.W. ; Magalhães, A. ; Sant'anna, C. ; Fraga, C.A.M . Structure-Property Relationship Studies of 3-Acyl-Substituted Furans: The Serendipitous Identification and Characterization of a New Non-Classical Hydrogen Bond Donor Moiety. New Journal of Chemistry, v. 44, p. 10994-11005, 2020.

 

Doi.org/10.1039/D0NJ01598A

 

 

Rodrigues, D. A ; Pinheiro, P. S. M. ; Sagrillo, F. S. ; Bolognesi, M. L. ; FRAGA, C. A. M. Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities. Medicinal Research Reviews, v. 40, p. 2177-2211, 2020.

 

Doi: 10.1002/med.21701

 

Cunha, T.T.S.; Souza, F. R.; Pinheiro, P. S.M.; Sant’anna, C. M.R.; NOËL, F.; França, T.C. C.; Fraga, C.A.M. Investigating the Molecular Basis for the Selective Inhibition of Aldehyde Dehydrogenase 2 by the Isoflavonoid Daidzin. CNS & Neurological Disorders-Drug Targets, v. 19, p. 437-447, 2020.

 

Doi: 10.2174/1871527319999200817153150

 

Viegas, C. ; Fraga, C. A. M.; Sousa, M. E. ; Tarozzi, A . Editorial: Oxidative Stress: How Has It Been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases?. Frontiers in Pharmacology, v. 11, p. 609274, 2020.

 

Doi:10.3389/fphar.2020.609274

Thorstenberg, M. L. ; Martins, M. D. A. ; Figliuolo, V. ; Silva, C.L. M ; Savio, L.E. ; Silva, R.C . P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1β Secretion. Mediators of Inflammation, v. 2020, p. 1-11, 2020.

 

Doi: 10.1155/2020/2545682

Oliveira, N.F.; Silva, C.L.M. Unveiling the potential of purinergic signaling in schistosomiasis treatment. Current Topics in Medicinal Chemistry, v. 20, p. 1, 2020.

Doi: 10.2174/1568026620666200924115113

 

Teixeira, R. G. S.; Pascual, R.; Araújo, K.G.L.; Brito, M. A. ; RIOS, C. ; C., A. F. ; Gandía, L. ; Silva, C. L. M. ; Machado, T. B. ; Santos, Wilson,C. In vitro and in silico studies for barbinervic acid, a triterpene isolated from Eugenia punicifolia that inhibits vasopressor tone. Natural Product Research. V. 1, p. 1-6, 2020.

Doi: 10.1080/14786419.2020.1739675

 

Pauli, F. P.; Martins, J. R.; Paschoalin, T. ; Ionta, M. ; Barbosa, M. L. C. ; Barreiro, E. J.  Novel VEGFR-2 inhibitors with an N -acylhydrazone scaffold. Archiv Der Pharmazie, v. 276, p. e2000130., 2020.

 

Alves, M. A.;Queiroz, A. C. ; Leite, A. B. ; Martins, F.T. ; Doriguetto, A. C. ; Barreiro, E. J. ; Moreira, M. S. A. ; Lima, L. M.  Carbamoyl- N -aryl-imine-urea: a new framework to obtain a putative leishmanicidal drug-candidate. RSC Advances, v. 10, p. 12384-12394, 2020.

 

Pedreira, J. G. B.; Nahidino, P.; Kudolo, M.; Pantsar, T.; Berger,B.T. ; Forster, M. ; Knapp, S.; Laufer, S. ; Barreiro, E. J.  Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors. Journal Of Medicinal Chemistry, v. 63, p. 7347-7354, 2020.

Doi:10.1021/acs.jmedchem.0c00508

 

Colodette, N. M.; Franco, L. S.; Maia, Rodolfo C.; Fokoue, H. H.; Sant’anna, C. M. R.; Barreiro, E. J.  Novel phosphatidylinositol 4-kinases III beta (PI4KIIIβ)  inhibitors discovered by virtual screening using free energy models. Journal Of Computer-aided Molecular Design, v. 34, p. 1091-1103, 2020.

Doi:10.1007/s10822-020-00327-9

 

Lima, L. M. ; Silva, B. N. M.; Barbosa, G. ; Barreiro, E. J. β-lactam antibiotics: An overview from a medicinal chemistry perspective. European Journal Of Medicinal Chemistry, v. 208, p. 112829, 2020.

Doi:10.1016/j.ejmech.2020.112829

Senger, M. R. ; Evangelista, T. C. S. ; Dantas, R. F. ; Santana, M. V. S. ; Gonçalves, L. C. S.; Neto, L. R.S. ; Ferreira, S. B. ; Junior, F. P.S . COVID-19: molecular targets, drug repurposing and new avenues for drug discovery. Memórias do Instituto Oswaldo Cruz, v. 115, p. 1, 2020.

Doi.org/10.1590/0074-02760200254 


Neto, L.R.S.; Filho, J.T.M. ; Neves, B.J. ; Maidana, R.L.B.R. ; Guimarães, A.C.R. ; Furnham, N. ; Andrade, C.H. ; Silva, F.P . In silico strategies to support fragment-to-lead optimization in drug discovery. Frontiers in Chemistry, v. 8, p. 1-18, 2020.

 

Doi.org/10.3389/fchem.2020.00093

Issy A.C.; Pedrazzi, J. F. C.; Van Oosten, A. B. S.; Checheto, T.; Silva, R. R.; Noel, F.; Del-bel, E.  Effects of doxycycline in Swiss mice predictive models of schizophrenia. Neurotoxicity Research, v. 101007, p. s1264002000268z, 2020.

 

Doi: 10.1007/s12640-020-00268-z

Silva, M. M. C.; Alencar, Nogueira, A.K.; Silva, J.S.; Montagnoli, T.L.; Silva, G.F.; Rocha, B.S.; Montes, G.C.; Otero, R.M.; Coelho, P.M.P.; Vasques, J. F.; Trahez, M.M.; Sudo, R.T.; Sudo, G.Z. Therapeutic Benefit of the Association of Lodenafil with Mesenchymal Stem Cells on Hypoxia-induced Pulmonary Hypertension in Rats. Cells, v. 9, p. 2120, 2020.

 

Doi: 10.3390/cells9092120.

Borsoi, M. ; Nunes, L. E. D. ; Barbosa, A. R. ; Lima, M. S. ; Medeiros, I. ; Pranke, M. A. ; Antonio, C. B. ; RATES, S. M. K. ; Neves, G.A.  Intermittent repeated stress but not ketamine changes mice response to antidepressants. Neuroscience Letters, p. 135452, 2020.

 

Doi: 10.1016/j.neulet.2020.135452

Silva, J. C.; Rodrigues, N. C.; Thompson'souza, G. A.; Muniz, V. S.; Neves, J. S.; Figueiredo, R. T.  Mac-1 triggers neutrophil DNA extracellular trap formation to Aspergillus fumigatus independently of PAD4 histone citrullination. Journal of Leukocyte Biology, v. 107, p. 69-83, 2020. 

Doi: 10.1002/JLB.4A0119-009RR

 

Nino, O. M.; Costa, C. S.; Torres, K. M.; Zanol, J. F.; Lima, L. C. F.; Alves, L.M.; Graceli, J. B. High refined carbohydrate diet leads to polycystic ovary syndrome-like features and reduced ovarian reserve in female rats. Toxicology Letters, v. 332, p. 42-55, 2020.

Doi.org/10.1016/j.toxlet.2020.07.002

 

Graceli, J. B.; Dettogni, R. S.; Merlo, E.; Nino, O. M.; Costa, C. S.; Zanol, J. F.; Morris, E. A. R. ; Alves, L.M. ; Denicol, A. C.  The impact of endocrine-disrupting chemical exposure in the mammalian hypothalamic-pituitary axis. Molecular and Cellular Endocrinology, v. 518, p. 110997-111017, 2020.

Doi.org/10.1016/j.mce.2020.110997

 

Junior, N. C.L.; Camilo, J. F.; Carmo, P. R.; Andrade, M. N.; Braz, B. F.; Santelli, R. E.; Gitirana, L. B.; Ferreira, A. C. F. ; Carvalho, D. P. ; Alves, L.M. ; Dias, G. R. M.  Subacute Exposure to Lead Promotes Disruption in the Thyroid Gland Function in Male and Female Rats. Environmental Pollution, 2020.

 

Doi:10.1016/j.envpol.2020.115889

Chagas, A.P.; Peixoto, B.P.; Costa, B.B.; Moreira, T.A.; Cinelli, L.P.; Silva, L.L.; Alves, L.M.; Junior, C.B. Effects of Bisphenol A and S on blood coagulation: in vivo, in vitro and in silico approaches in toxicodynamic. Toxicology Mechanisms and Methods, v. 31, p. 1-34, 2020.
 

Doi:10.1080/15376516.2020.1836102

Almeida, J.; Oliveira, V.R.; Avelar, J.L.S.; Moita, B.S.; Lima, L.M. COVID-19: Physiopathology and Targets for Therapeutic Intervention. Revista Virtual de Química, v. 12, p. 0000, 2020.

Curnow, A. C.; Gonsalez, S. R.; Gogulamudi, V. R.; Visniauskas, B. ; Simon, E. E. ; Gonzalez, A. A. ; Majid, D. S. A. ; Lara, L.S. ; Prieto, M. C.  Low Nitric Oxide Bioavailability Increases Renin Production in the Collecting Duct. Frontiers in Physiology, v. 11, p. 153, 2020.

 

Doi.org/10.3389/fphys.2020.559341

 

Oriiz, M.; Coutinho, D. S.; Ciambarella, B. T.; Souza, E.; Leite, A. P.; Durli, T. L.; Silva, P. M. R.; Bernardi, A.; Sonvico, F.; Pohlmann, A. R.; Martins, M. A.; Guterres, S. S. Intranasal administration of budesonide-loaded nanocapsule-microagglomerates as an innovative strategy for asthma treatment. Drug Delivery and Translational Research, 2020.

Doi.org/10.1007/s13346-020-00813-5

 

Coutinho, D. S.; Pires, J.; Gomes, H.; Pohlmann, A.; Guterres, S.; Silva, P. M. R. E.; Ferrarini, S.; Bernardi, A.; Martins, M.A. Pequi (Caryocar brasiliense Cambess)-Loaded Nanoemulsion, Orally Delivered, Modulates Inflammation in LPS-Induced Acute Lung Injury in Mice. Pharmaceutics, v. 12, p. 1075, 2020.

 

Doi: 10.3390/pharmaceutics12111075.

Insuela, D. B. R.; Ferrero, M.R.; Coutinho, D. S.; Martins, M. A.; Carvalho, V. F. Could Arachidonic Acid-Derived Pro-Resolving Mediators Be a New Therapeutic Strategy for Asthma Therapy?. Frontiers in Immunology, v. 11, p. 1-9, 2020.

 

Doi:10.3389/fimmu.2020.580598

 

Mello, F.V.C.; Quaresma, B.M.C.S.; Pitombeira, M.C.R.; Brito, M.A.; Farias, P.P.; Castro, S.L.; Salomão, K.; Carvalho, A.S.; Paula, J.I.O.; Nascimento, S.B.; Cupello, M.P.; Paes, M.C; Boechat, N.; Felzenszwalb, Israel . Novel nitroimidazole derivatives evaluated for their trypanocidal, cytotoxic, and genotoxic activities. EUROPEAN Journal of Medicinal Chemistry, v. 186, p. 111887-111902, 2020.

Doi: 10.1016/j.ejmech.2019.111887


Boechat, N.; Carvalho, R. C.C. ; Ferreira, M.L. G. ; Coutinho, J.P.; Sa, P.M. ; Seito, L. N. ; Rosas, E. C. ; Krettli, A.U. ; Bastos, M. M. ; Pinheiro, L. C.S.  Antimalarial and anti-inflammatory activities of new chloroquine and primaquine hybrids: Targeting the blockade of malaria parasite transmission. Bioorganic & Medicinal Chemistry, v. 28, p. 115832-115846, 2020.

Doi: 10.1016/j.bmc.2020.115832.

Pinheiro, L.C.S.; Hoelz, L.V.B.; Ferreira, M.L.G.; Oliveira, L.G.; Pereira, R.F.A.; Valle, A.M.; André, L.S.P.; Scaffo, J.; Pinheiro, F.R.; Ribeiro, T.A.N.; Sachs, D.; Pascoal, A.C.R.F.; Boechat, N.; Aguiar'alves, F. Synthesis of benzoylthiourea derivatives and analysis of their antibacterial performance against planktonic Staphylococcus aureus and its biofilms. Letters in Applied Microbiology, v. 71, p. 645-651, 2020.

Doi.org/10.1111/lam.13359


Souza, A. A. A. ; Torres, L. R. ; Capobianco, L. R. P. L. ; Paula, V. S. ; Cascabulho, C. M. ; Salomao, K. ; Almeida, M. G. B. ; Ferreira, M.L G. ; Boechat, N. ; Pinheiro, L. C. S. ; Souza, E. M.  Chloroquine and Sulfadoxine Derivatives Inhibit ZIKV Replication in Cervical Cells. Viruses-Basel, v. 13, p. 1-15, 2020.

 

Doi: 10.3390/v13010036.


Martins, D.L.; Borges, A.A.; Silva, N. A.; Faria, J.V.; Hoelz, L.V.B.; Souza, H.V.C.M.; Bello, M.L.; Boechat, N.; Ferreira, V.F.; Faria, R.X. P2X7 receptor inhibition by 2-amino-3-aryl-1,4-naphthoquinones. Bioorganic Chemistry, v. 104, p. 104278-104289, 2020.

Doi: 10.1016/j.bioorg.2020.104278.


Ferreira, T. P. T.; JG, Lima; Filho, F.F. ; SA, Y. A. P. J. ; AC, Arantes ; Guimaraes, F. V. ; V, Carvalho ; Hogaboam, C M ; J, Wallace ; Martins, M. A. ; Silva, PM . Intranasal Flunisolide Suppresses Pathological Alterations Caused by Silica Particles in the Lungs of Mice. Frontiers in Endocrinology, v. 11, p. 388, 2020.

 

Doi:10.3389/fendo.2020.00388


Ventura, R. D. ; Chaves, A. S. ; Magalhaes, N. S. ; Gonzalez, F. B. ; Pacini, M. F. ; Perez, A. R. ; Silva, P. M. R. ; M.A., Martins ; VF, Carvalho . Activation of PPARγ reduces N-acetyl-cysteine -induced hypercorticoidism by down-regulating MC2R expression into adrenal glands. Free Radical Biology and Medicine, v. 156, p. 137-143, 2020.


Nunes, I. K. C.; Souza, E. T.; Martins, I. R. R.; Barbosa, G. ; Junior, M. O. M.; Medeiros, M. M. ; Silva, S. W. D. ; Balliano, T. L. ; Silva, A. B. ; Silva, P. M. R. ; VF, Carvalho ; Martins, M. A. ; Lima,L.M . Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies. European Journal of Medicinal Chemistry, v. 204, p. 112492, 2020.

Doi: 10.1016/j.ejmech.2020.112492. 


Carvalho, K.I.M. ; Coutinho, D.S. ; Joca, H.C. ; Miranda, A.S. ; Cruz, J.S. ; Silva, E.T. ; Souza, M.V. N.; Faria, R.X. ; Silva, P.M.R. ; Costa, J.C.S. ; Martins, M.A. Anti-Bronchospasmodic Effect of JME-173, a Novel Mexiletine Analog Endowed With Highly Attenuated Anesthetic Activity. Frontiers in Pharmacology, v. 11, p. 1159, 2020.

 

Doi.org/10.3389/fphar.2020.01159

Cavalieri,I.C.P.; Valenca, H. M. ; Moraes, J.A. ; Gitirana, L.B.; Souza, B.R. ; Schmidt, M ; Valença, S.S . Dimethyl Fumarate Attenuates Lung Inflammation and Oxidative Stress Induced by Chronic Exposure to Diesel Exhaust Particles in Mice. International Journal of Molecular Sciences, v. 21, p. 9658, 2020.

Doi: 10.3390/ijms21249658.

Nascimento, M.S.S. ; Câmara, V.R.F. ; Costa, J.S. ; Barbosa, J.M.C. ; Lins, A.S.M. ; Salomão, K. ; Castro, S.L.; Carvalho, S.A. ; Silva, E.F. ; Ferreira. E.;  ; Fraga, C.A.M. Identification of novel functionalized carbohydrazonamides designed as Chagas disease drug candidates. Medicinal Chemistry , v. 16, p. 774-783, 2020.

 

Doi:10.2174/1573406415666190627103013

Araujo-montoya, B.O. ; Senger, M.R. ; Gomes, B.F. ; Harris, G. ; Owens, R.J. ; Silva-jr, F.P.  Schistosoma mansoni cathepsin D1: Biochemical and biophysical characterization of the recombinant enzyme expressed in HEK293T cells. Protein Expression and Purification, v. 167, p. 105532, 2020.

 

Doi:10.1016/j.pep.2019.105532

Azalim, P. ; Monte, F.M. ; Rendeiro, M. M. ; Liu, X. ; Odoherty, G. A. ; Fontes, C. F. ; Leitão, S. G. ; Quintas, L. E. M. ; Noël, F. Conformational states of the pig kidney Na+/K+-ATPase differently affect bufadienolides and cardenolides: A directed structure-activity and structure-kinetics study. Biochemical Pharmacology , v. 171, p. 113679, 2020.

 

Doi: 10.1016/j.bcp.2019.113679

Costa, G. ; Montagnoli, T. L. ; Da SILVA, J. S. ; Alencar, A. K. N. ; Gamba, L. E.R. ; Alves, B. E.O. ; Moraes, M. C. ; Trachez, M. M ; Nascimento, J. H.M. ; Coelho, P.M.P. ; Mendez-otero, R. ; Lima, L.M. ; Barreiro, E.J. ; Sudo, Roberto Takashi ;  Sudo, G.Z . New benzofuran N-acylhydrazone reduces cardiovascular dysfunction in obese rats by blocking TNF-alpha synthesis. Drug Design Development and Therapy , v. 14, p. 3337-3350, 2020.

 

Doi: 10.2147/DDDT.S258459

Pereira, P.R. ; Macedo, S. ; Gaspar, T. B. ; Canberk, S. ; Selmi-ruby, S. ; Maximo, V. ; Soares, P. ;  Alves, L. M. Relevant dose of the environmental contaminant, tributyltin, promotes histomorphological changes in the thyroid gland of male rats. Molecular and Cellular Endocrinology , v. 502, 2020.

 

Doi: 10.1016/j.mce.2019.110677

 

3.

Reis, E.M. ; Nobre, C. C. G. ; Chagas, A.P. ;  Alves, L.M. ; Junior, C.B . Effects of TSH in Erythrocyte Osmotic Fragility: Signalling Pathway. International Journal of Blood Research and Disorders, v. 7, p. 1-7, 2020.

 

Doi: 10.23937/2469-5696/1410048

Lindoso, RS ; Lopes, J.A. ; Binato, R. ; Abdelhay, E. ; Takiya, C.M. ; Miranda, K.R. ; Lara, L. S. ; Viola ,A ; Bussolati, B ; Vieyra, A. ; Collino F . Adipose Mesenchymal Cells-Derived EVs Alleviate DOCA-Salt-Induced Hypertension by Promoting Cardio-Renal Protection. Molecular Therapy-Methods & Clinical Development, v. 16, p. 63-77, 2020.

Doi:10.1016/j.omtm.2019.11.002

Dick, C. F. ; Guimarães, L.M. ; Kelly, L.F.C. ; Cortes, A.L. ;  Morcillo, L.L.S. ; Sampaio, L.S. ; Fernandes, J. R.M. ; Vieyra, A. . A ferric reductase of Trypanosoma cruzi (TcFR) is involved in iron metabolism in the parasite. Experimental Parasitology, v. 217, p. 107962, 2020.

Doi:10.1016/j.exppara.2020.107962

 

Lima, J. A. ; R. Costa, T.W. ; Fonseca, A. C.C. ; Amaral, R. F. ; Nascimento, M.D. S.B. ; Filho, O.A.S. ; Miranda, A.L.P. ; Neto, D.C.F.; Lima, F.R.S. ; Hamerski, L. ; Tinoco, L. W.  Geissoschizoline, a promising alkaloid for Alzheimer?s disease: Inhibition of human cholinesterases, anti-inflammatory effects and molecular docking. Bioorganic chemistry, v. 104, p. 104215, 2020.

Nunes, I.C.N. ; Souza, E.T. ; Martins, I.R.M. ; Barbosa, G. ; Junior, M.O.N. ; Medeiros, M.M. ; Silva, S. W.D. ; Balliano, T.L.; Silva, B.A. ; Silva, P.M.R.; Carvalho, V.F. ; Martins, M.A.; Lima, L.M.  Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 204, p. 112492, 2020.

DOI: 10.1016/j.ejmech.2020.112492

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Giorno, T.B.S.; Lima, F.A.; Brand, A.L.M.; Oliveira, C.M. ; Rezende, C.M. ; Fernandes, P.D.  Characterization of βN-Octadecanoyl-5-hydroxytryptamide Anti-Inflammatory Effect. Molecules, v. 26, p. 3709-3722, 2021.


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Donald, G.R. ; De Carvalho, P.R. ; Fernandes, P.D. ; Boylan, F . Antinociceptive activity of puberulin and choisyine from ethanol extract of Choisya ternata Kunth var. Sundance. Biomedicine & Pharmacotherapy, v. 141, p. 111926, 2021.

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Teixeira-Cruz, J.M. ; Strauch, M.A. ; Monteiro-Machado, M. ; Tavares-Henriques, M.S. ; De Moraes, J.A. ; Ribeiro da Cunha, L.E. ; Ferreira, R.S.Jr. ; Barraviera, B. ; Quintas, L.E.M. ; Melo, P.A . A Novel Apilic Antivenom to Treat Massive, Africanized Honeybee Attacks: A Preclinical Study from the Lethality to Some Biochemical and Pharmacological Activities Neutralization. Toxins, v. 1111, p. 1111-11, 2021.

 

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Borges, P.A. ; Waclawiak, I. ; Georgii, J.L. ; Fraga-Junior, V.S. ; Barros, J.F. ; Lemos, F.S. ; Russo-Abrahão, T. ; Saraiva, E.M. ; Takiya, C.M. ; Coutinho-Silva, R. ; Penido, C. ; Mermelstein, C.; Meyer-Fernandes, J.R. ; Canto, F.B. ; Neves, J.S. ; Melo, P.A. ; Canetti, C. ; Benjamim, C.F. Adenosine Diphosphate Improves Wound Healing in Diabetic Mice Through P2Y12 Receptor Activation. Frontiers in Immunology, v. 12, p. 1111-11111, 2021.

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Martino, T. ; Kudrolli, T.A. ; Kumar, B. ; Salviano,I. ; Mencalha,A. ; Coelho, M.G.P. ; Justo, G. ; Costa, P.R.R. ; Sabino, K.C.C.; Lupold, S.E . The orally active pterocarpanquinone lqb-118 exhibits cytotoxicity in prostate cancer cell and tumor models through cellular redox stress. Prostate, v. 78, p. 140-151, 2018.

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Frattani, F.S. ; Lima, L.M. ; Barreiro, E.J. ; Zingali, R.B. The antithrombotic and haemostatic effects of lassbio-752: a synthetic, orally active compound in an arterial and venous thrombosis model in rats. Journal of pharmacy and pharmacology , v. 69, p. 1374-1380, 2017.

 

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Sacramento, C.Q.M.; Freitas, C.S.G.; Rocha, N.H.; Miranda,L.V.B.; rodrigues, natalia Marttorelli,M.F.; Ferreira, A.C.A.; Lima, G.A.B.; Vieira,J.L.; Bastos,Y.R.; Volotão,M.M; Nunes, E.M.; Tschoeke,E.P. ;Leomil,D.A. Loiola,L. Trindade, E.C.; Rehen,P.; Bozza,S.K.; Bozza,F.A.;  Patrícia T.;  Boechat, N.T.; Filippis,F.L. Ana M. B.  Corrigendum: the clinically approved antiviral drug sofosbuvir inhibits zika virus replication. Scientific reports, v. 7, p. 46772, 2017.

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Sobrinho, A.P.; Minho, A.S. ; Ferreira, L.L.C. ; Martins, G.R. ; Boylan, F. ; Fernandes, P.D . Characterization of anti-inflammatory effect and possible mechanism of action of action of Tibouchina granulosa. Journal of pharmacy and pharmacology , v. 1, p. Early view, 2017.

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Silva, E.R. ; Bizzo, H.R. ; Fernandes, P.D. ; Junior, V.F.V. ; Leitão, S.G. ; Oliveira, D.R. Development and evaluation of an inhalation chamber for in vivo tests. Anais da academia brasileira de ciencias , v. 1, p. 1-11, 2017.

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Guerra, F.S.; Oliveira, R.G.; Fraga, C.A.M.; Mermelstein, C.S.; Fernandes, P.D . Rock inhibition with fasudil induces beta-catenin nuclear translocation and inhibits cell migration of mda-mb 231 human breast cancer cells. Scientific reports , v. 7, p. 13723, 2017.

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Leitão, G.G. ; Pereira, J.P.B. ; Carvalho, P.R. ; Ropero, D.R. ; Fernandes, P. D. ; Boylan, F . Isolation of quinoline alkaloids from three choisya species by high-speed countercurrent chromatography and the determination of their antioxidant capacity. Revista brasileira de farmacognosia-brazilian journal of pharmacognosy , v. 27, p. 297-301, 2017.

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Kartbaeva, E.B. ; Donald, G.R. ; Sakipova, Z.B. ; Ibragimova, L.N. ; Bekbolatova, E.N. ; Ternynko, I.I. ; Fernandes, P.D. ; Boylan, F.  Antinociceptive activity of cistanche salsa stolons, growing in the republic of kazakhstan. Revista brasileira de farmacognosia-brazilian journal of pharmacognosy , v. 27, p. 587-591, 2017.

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Silva, E.R. ; Oliveira, D.R. ; Fernandes, P.D. ; Bizzo, H.R. ; Leitão, S.G . Ethnopharmacological evaluation of breu essential oils from protium species administered by inhalation. Evidence-based complementary and alternative medicine , v. 2017, p. 1-10, 2017.

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Simas, D.L.R. ; Reyes, M.S.M. ; Wug, M.A.M. ; Cordeiro, M.S. ; Giorno, T.B.S. ; Taracena, E.A. ; Hernández, B.E.O. ; Arévalo, J.V.M. ; Fernandes, P.D. ; Sabino, J.F.P. ; Silva,A.J.R. Chemical composition and evaluation of antinociceptive activity of the essential oil of cav. From guatemala. Natural product research , v. 1, p. 1-3, 2017.

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Amorim, J.L. ; Figueiredo, J.B. ; Amaral, A.C.F. ; Barros, E.G.O. ; Palmero, C. ; Palantinos, M.A. ; Ramos, A.S. ; Ferreira, J.L.P. ; Silva, J.R.A. ; Benjamim, C.F. ; Basso, S.L. ; Nasciutti, L.E.  ; Fernandes, P.D.  Wound healing properties of copaifera paupera in diabetic mice. Plos one , v. 12, p. E0187380, 2017.

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Ribeiro,T. ; Oliveira, J.T. ; Almeida,F.M. ; Tomaz, M.A.; Melo, P.A. ; Marques, S.A. ;  Andrade, G.M. ; Martinez, A.M.B . Blockade of atp p2x7 receptor enhances ischiatic nerve regeneration in mice following a crush injury. Brain research , v. 115, p. 1111-11112, 2017.

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Galvão, I. ; Vago, J. P. ; Barroso, L. C. ; Tavares , L.P.; Junior , C.M.Q.; Costa, V. V. ; Carneiro, F. S. ; Ferreira, T. P. T. ;  Silva , P.M.; Amaral, F. A. ; Souza , L.P.; Teixeira, M. M.  Annexin a1 promotes timely resolution of inflammation in murine gout. European journal of immunology, v. 47, p. 585-596, 2017.

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Oliveira, L. G. ; Testasicca, M. C.S. ; Vargo , J.P.; Figueiredo, A. B. ; Canavaci, A. ; perucci, L. O. ; Ferreira, T. P. T. ; Coelho, E. A. F. ; Goncalves, D. U. ; Rocha, M. O. C. ; Silva , P;M.; Ferreira, C. N. ; Junior, C.Q. ; Souza, L.P.; Fernandes, A. P. Annexin a1 is involved in the resolution of inflammatory responses during leishmania braziliensis infection. Journal of immunology, v. 198, p. 3227-3236, 2017.

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Dalmeida, A. P. L.; Silva , P.M.; Chiambarella, B.T. ; Martins, M.A. ; Bernardi, A.  Α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice. International journal of nanomedicine, v. Volume 12, p. 4479-4491, 2017.

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Coutinho, D.S. ; Valotta, E.A.A. ; Nascimento, C.V. M. F. ; Pires, A.L.A. ; Napimoga, M.H.; Carvalho, V.F. ; Torres, R.C. ; Silva, P.M. R. ; Martins, M.A. 15-deoxy-delta-12,14-prostaglandin j2 inhibits lung inflammation and remodeling in distinct murine models of asthma. Frontiers in immunology, v. 8, p. 1-12, 2017.

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Ribeiro, E.L. ; Fragoso, I.T. ; Gomes, F.O.S. ; Oliveira, A.C. ; Silva, A.K.S.  ; Silva, P.M.; Ciambarella, B.T. ; Ramos, I.P.R. ; Peixoto, C.A . Diethylcarbamazine: a potential treatment drug for pulmonary hypertension?. Toxicology and applied pharmacology, v. 333, p. 92-99, 2017.

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Costa, P.R.R. Interaction between bioactive compound 11a-n-tosyl-5-deoxi-pterocarpan (lqb-223) and calf thymus dna: spectroscopic approach, electrophoresis and theoretical studies. International journal of biological macromolecules, alemanha, v. 96, p. 223-233, 2017.

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Scatena, G.S. ; Cassiano, N.M. ; Netto, C.D. ; Costa, P.R.R. ; Cass, Q.B. ; Batista, J.M.  Preparative chiral separation and absolute configuration of the synthetic pterocarpanquinone lqb-118. Chirality, v. 29, p. 167-171, 2017.

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Cupello, M.P. ; Saraiva, F.M. ; Ippolito, P. ; Fernandes, A.S. ; Barreto, R.F.S.M. ; Costa, D.S.S. ; Paula, J.I.O. ; Costa, P.R.R. ; Nogueira, N.P. ; Felzenswalb, I. ; Dias, A.G. ; Paes, M.C. Mutagenic and cytotoxicity lqb 123 profile: safety and tripanocidal effect of a phenyl-t-butylnitrone derivative. Biomed research international, v. 2017, p. 1-8, 2017.

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Costa, P.R.R.; Cívicos, J. ; Coimbra, J. Solvent-free synthesis of salen ligands and pd(ii)- and cu(ii)-salen complexes: their use in the oxidation of α-tetralones to α-naphthols. Synthesis-stuttgart, v. 49, p. A-1, 2017.

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Cívicos, J. ; Costa, P.R.R. ; Domingos, J. Palladium-catalyzed α-arylation of dimethyl malonate and ethyl cyanoacetate with o-alkoxybromobenzenes for the synthesis of phenylacetic acid, esters and phenylacetonitriles. Synopen, v. 01, p. 0091-0096, 2017.

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Ribeiro,V.P. ; Melo, A.C.; Feitosa, E.K. ; Reis, A.G. ; Barroso, M.V. ; Cavalieri, I.C. ; Carvalho, G.M.C. ; Zin, W.A. ; Porto, L.C. ; Gitirana, L.B. ; Lanzetti, M. ; Valença, S.S. Atorvastatin and simvastatin promoted mouse lung repair after cigarette smoke-induced emphysema. Inflammation, v. 40, p. 965-979, 2017.

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Nesi, R.T. ; Feitosa, E.K.; Lanzetti, M. ; Ávila, M.B.; Magalhães, C.B. ; Zin, W.A. ; Faffe, D.S. ; Porto,L.C. ; Valença, S.S . Inflammatory and oxidative stress markers in experimental allergic asthma. Inflammation, v. 40, p. 1166-1176, 2017.

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Cavalieri,I.C. ; Reis, A.G. ; Feitosa, E.K. ; Ribeiro, V.P. ; Lanzetti, M. ; Gitirana, L.B. ; Souza, B.R. ; Porto, L.C. ; Valença, S.S . Pulmonary emphysema cross-linking with pulmonary fibrosis and vice versa: a non-usual experimental intervention with elastase and bleomycin. Inflammation, v. 40, p. 1487-1496, 2017.

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Nesi, R.T. ; Barroso, M.V. ; Muniz, V.S. ; Arantes, A.C.; Martins, M.A. ; Gitirana, Lycia ; Neves, J.S. ; Benjamim, C.F. ; Lanzetti, M. ; Valença, S.S . Pharmacological modulation of reactive oxygen species (ros) improves the airway hyperresponsiveness by shifting the th1 response in allergic inflammation induced by ovalbumin. Free radical research, v. 51, p. 708-722, 2017.

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Barroso, M.V.; Cavalieri, I.C. ; Gitirana, L.B.; Fautrel, A. ; Lagente,V. ; Schmidt, M. ; Porto, L.C. ; Souza, B.R. ;  Valença, S.S.; Lanzetti, M . Propolis reversed cigarette smoke-induced emphysema through macrophage alternative activation independent of nrf2. Bioorganic & medicinal chemistry, v. 25, p. 5557-5568, 2017.

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Silva, C.O. ; Costa, A.M.A. ; Martins, M.R. ; Nascimento, F.V. ;  Valença, S.S. ; Lagente, V. ; Pôrto,L. ; Victoni,T . Time course of the phenotype of blood and bone marrow monocytes and macrophages in the lung after cigarette smoke exposure in vivo. International journal of molecular sciences, v. 18, p. 1940, 2017.

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Abe,F.S.F.A. ; Cunha, R.L.D.; Salomon, P.S.; Júnior, E.R.; Valença, S.S. ; Gitirana , L.B . Nanoecotoxicological effects of a sunscreen formulation based on tio2 nanoparticles on microalgae from guanabara bay (rio de janeiro, brazil). Moj polymer science, v. 1, p. 1-9, 2017.

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Ribeiro, V.M. ; Bede, T.P. ; Rocha, G. ; Barroso, S. ; Valença, S.S. ; Azeredo, V.B . High fat diet and high polyphenols beverages effects in enzymatic and non-enzymatic antioxidant activity. Nutricion hospitalaria, v. 24, p. 169-175, 2017.

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Matias, I. ; Diniz, L. P. ; Buosi, A. S. ; Neves, G. ; Stipursky, J. ; Gomes, F. C. A. . Flavonoid Hesperidin Induces Synapse Formation and Improves Memory Performance through the Astrocytic TGF-?1. Frontiers in Aging Neuroscience, v. 9, p. 184, 2017.

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Neves, G.; Borsoi, M.;, ANTONIO, C.; PRANKE, M.A.; BETTI, A. H.;  RATES, M.S.K. Is Forced Swimming Immobility a Good Endpoint for Modeling Negative Symptoms of Schizophrenia? - Study of Sub-Anesthetic Ketamine Repeated Administration Effects. Anais da Academia Brasileira de Ciências, 89(3), 1655-1669. 2017.

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2016

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Neto, L.A.S. ; Trajano, E.T.L. ; Lanzetti, M. ; Mendonça , M.S.A.; Guilherme, R. ; Figueiredo, R. T. ; Benjamim, C.F. ; Valença, S.S. ; Costa, A.M.A. ; Porto, L.C.M.S . Elastase modifies bleomycin-induced pulmonary fibrosis in mice. Acta histochemica (print), v. 118, p. 203-212, 2016.

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Casanova, L.M. ; Netto, J.M.E. ; Tinoco, L.W.; Penna, M.S. ; Costa, S.S . The use of nmr metabolite profiling and hypoglycemic assay for comparison of unfractionated aqueous leaf extracts of two species. Chemistry & biodiversity (print) , v. 13, p. 1-9, 2016.

 

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Wang, H ; Sun, x. ; Sudo, G.Z. ; Lin,M.  ; Groban,L.  Cardiomyocyte-specific deletion of the g protein-coupled estrogen receptor (gper) leads to left ventricular dysfunction and adverse remodeling: a sex-specific gene profiling analysis. Biochimica et biophysica acta. Molecular basis of disease , v. S0925, p. 30247, 2016.

 

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Wang, H. ; Alencar, A. ; Lin, M. ; Sun, X. ; Sudo, R.T. ; Sudo, G.Z. ; Lowe, D.A. ; Groban, L. Activation of gpr30 improves exercise capacity and skeletal muscle strength in senescent female fischer344 × brown norway rats. Biochemical and biophysical research communications (print) , v. 475, p. 81-86, 2016.

 

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Wang, H. ; Silva,J. ; Alencar, A. ; Sudo,G.Z. ; Lin, M.S. ; Sun, X. ; Ahmad, S. ; Ferrario, C.M. ; Groban, L . Mast cell inhibition attenuates cardiac remodeling and diastolic dysfunction in middle-aged, ovariectomized fischer344×brown norway rats. Journal of cardiovascular pharmacology , v. 68, p. 1-57, 2016.

 

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Alencar, A.K. ; Montes, G.C. ; Montagnoli, T.L. ; Silva, A.M.S. ; Martinez, S.T. ; Fraga, A.G. ; Wang, H. ; Groban, L. ; Sudo,R.T. ; Sudo, G.Z . Activation of gper ameliorates experimental pulmonary hypertension in male rats. European journal of pharmaceutical sciences , v. 97, p. 208-217, 2016.

 

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López, K.S.E. ; Marques, A.M. ; Moreira, D.L. ; Velozo, L.S. ; Sudo, R.T. ; Sudo, G.Z. ; Guimarães, E.F. ; Kaplan, M.A.C.  Local anesthetic activity from extracts, fractions and pure compounds from the roots of ottonia anisum spreng. (piperaceae). Anais da academia brasileira de ciências (online) , v. 88, p. 2229-2237, 2016.

 

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Serra, M.F. ;  Neves, J.S. ; Couto, G.C. ; Cotias, A.C. ; Pão, C.R. ; Olsen, P.C. ; Carvalho, K.I.M. ; Valotta, E.A. ; Faria, R.X. ; Costa, J. ; Cordeiro, R. ; Silva, P.M.R. ; Martins, M . Jm25-1, a lidocaine analog combining airway relaxant and antiinflammatory properties. Anesthesiology (philadelphia) , v. 124, p. 109-120, 2016.

 

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Carmo, L. A. S. ; Bonjour, K. ; Ueki, S. ; Neves, J. S. ; Liu, L. ; Spencer, L. A. ; Dvorak, A. M. ; Weller, P. F. ; Melo, R. C. N. . Cd63 is tightly associated with intracellular, secretory events chaperoning piecemeal degranulation and compound exocytosis in human eosinophils. Journal of leukocyte biology , v. 100, p. 391-401, 2016.

 

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Coutinho, J. V. ; Freitas, F. F. ; Freitas, F. P. ; Porto, M. L. ; Meyrelles, S. S. ; Vasquez, E. C. ; Brandao, P. A. ; Melo, F. D.P. ; Carneiro, M. T. ; Alves, L.M. ; Silva, I. V. ; Gava, A. L. ; Gracelli, J. B.  Tributyltin chloride induces renal dysfunction by inflammation and oxidative stress in female rats. Toxicology letters , v. 16, p. 33094-33094, 2016.

 

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Merlo, E. ; Podratz, P.L. ; Sena, G.C. ; Araújo, J.F.P. ; Lima, L.C.F. ; Alves, I.S.S. ; Souza, L.N.G. ; Pelição, R. ; Rodrigues, L.C.M. ; Brandão, P.A.A. ; Carneiro, M.T.W.D. ; Pires, R.G.W. ; Silva, C.M. ; Alarcon, T.A. ; Alves, L.M. ; Silva, I.V. ; Graceli, J.B.  The environmental pollutant tributyltin chloride disrupts the hypothalamic-pituitary-adrenal axis at different levels in female rats. Endocrinology (philadelphia) , p. En.2015-1896-xxx, 2016.

 

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Lima,L.M.Sudo, G.Z. ; Nunes, I.K.C. ; Araujo, J.S.C.   ; Silva, J. ; Trachez, M.M. ;  Silva, T.F. ; Costa, F.P. ; Sudo, R.T. ; Barreiro, E.J . Synthesis, solubility, plasma stability, and pharmacological evaluation of novel sulfonylhydrazones designed as anti-diabetic agents. Drug design, development and therapy , v. Volume 10, p. 2869-2879, 2016.

 

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Jimenez, S.E. ; Herrera, A.M. ; Olivares, R.R. ; Gonzalez, E.D. ; Torres, B.N. ; Oliveira, E. ; Romeiro, N. ; Lima, L.M. ; Palos, I. ; Rivera, G . Synthesis, biological evaluation and molecular docking of new benzenesulfonylhydrazone as potential anti-trypanosoma cruzi agents. Medicinal chemistry , v. 12, p. 1-1, 2016.

 

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Silva, A.L. ; Magalhaes, R. ; Branco, V. ; Silva, J. ; Cruz, f. ; Marques, P. ; Ferreira, T. P. T. ; Morales, M. ; Martins, M. A. ; Rocco, P. R. M. The tyrosine kinase inhibitor dasatinib reduces lung inflammation and remodelling in experimental allergic asthma. British journal of pharmacology, v. 173, p. 1236-1247, 2016.

 

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Alberto, A. V. P. ; Faria, R.X.  ; Menezes, J. R. L. ; Surrage, A. ; Rocha, N.C. ; Ferreira, L.G.B. ; Frutuoso, V.S. ; Martins, M. A. ; Alves, L.A . Role of p2 receptors as modulators of rat eosinophil recruitment in allergic inflammation. Plos one, v. 11, p. E0145392, 2016.

 

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Ferreira, T.P.T. ; Mariano,L.L.; Bortolini, R.G.; Arantes,A.C.S.; Fernandes,A.J.; Berni, M.; Cecchinato, V.; Uguccioni, M.; Maj,R.; Barberis, A.; Silva,P.M.R.; Martins,M.A. Potential of pegylated toll-like receptor 7 ligands for controlling inflammation and functional changes in mouse models of asthma and silicosis. Frontiers in immunology (online), v. 7, p. 1, 2016.

 

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Torres,R.C  ; Magalhães,N.S; e Silva,P.M.R. ; Martins,M.A. ; Carvalho,V.F.  Activation of ppar-γ reduces hpa axis activity in diabetic rats by up-regulating pi3k expression. Experimental and molecular pathology (print), v. 101, p. 290-301, 2016.

 

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Lemes, L.F.N. ; Ramos, G.A.; Oliveira,A.S.; Silva,F.M.R. ; Couto, G.C. ; Boni, M.S. ; Guimarães,M.J.R. ; Souza,I.N.O. ; Bartolini, M.; Andrisano, V.; Nogueira,P.C.N.; Silveira,E.R.; Brand,G.D. ; Soukup, O. ; Korábeč ; Romeiro,N.C.; Castro,N.G. ; Bolognesi,M.L.; Romeiro, L.A.S.  Cardanol-derived ache inhibitors: towards the development of dual binding derivatives for alzheimer's disease. European journal of medicinal chemistry, v. 108, p. 687-700, 2016.

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Petronilho, E.C. ; Rennó,M.N.; Castro,N.G.; Silva,F.M.R. ; Pinto, A.C. ; Villar,  J.D.F . Design, synthesis, and evaluation of guanylhydrazones as potential inhibitors or reactivators of acetylcholinesterase. Journal of enzyme inhibition and medicinal chemistry (online), v. 31, p. 1-10, 2016.

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Viana,J. B.N. ; Carvalho, A. R. ; Nasciutti, L. E. ; Hernandez, R.A. ; Silva, F.C. ; Souza, P. A. R. ; Romeiro, L. A. ; Sainz, J. A.G. ; Noel, F.G. ; Silva, C. L. M.  New multi-target antagonists of  1a-,  1d-adrenoceptors and 5-ht1a receptors reduce human hyperplastic prostate cell growth and the increase of intraurethral pressure. The journal of pharmacology and experimental therapeutics (online) , v. 356, p. 212-222, 2016.

 

Costa, L.B. ; Cardoso,M.V.O.; Filho, G.B.O.; Gomes, P.A. T.O. ; Espíndola, J.W.P ; Silva, T.G. J. ; Torres, P.H.M. ; Júnior, F.P.S. ; Martin,J. ; Figueiredo, R.C.B.Q. ; Leite, A.C.L.  Compound profiling and 3d-qsar studies of hydrazone derivatives with activity against intracellular trypanosoma cruzi. Bioorganic & medicinal chemistry (print) , v. 24, p. 1608-1618, 2016.

 

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Neves, B.J. ; Dantas, R.F. ; Senger, M.R. ; Valente, W.C.G. ; Neto, J.M.R. ; Chaves, W.T. ; Kamentsky, L. ; Carpenter, A. ; Júnior, F.P.S. ; Andrade, C.H. The antidepressant drug paroxetine as a new lead candidate in schistosome drug discovery. Medchemcomm , p. 1176-1182, 2016.

 

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Lima, J. A. ; Costa, T. W. R. ; Silva, L. L.; Miranda, A. L. P. ; Pinto, A. C . Antinociceptive and anti-inflammatory effects of a geissospermum vellosii stem bark fraction. Anais da academia brasileira de ciências (online), p. 1-12, 2016.

 

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