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2019

 

Silva, J.S. ; Sun,X. ; Ahmad, S. ; Wang, H. ; Sudo, R.T. ; Varagic,J. ; Ferrario, C.M. ;  Sudo, G.Z. ; Groban, L . G-Protein-Coupled-Estrogen agonist g1 improves diastolic function and attenuates cardiac ras activation in estrogen-deficient hypertensive rats. Journal of cardiovascular pharmacology , v. 1, p. 1, 2019.

 

Doi: 10.1097/fjc.0000000000000721

Felix, N.S. ; Mendonça,L. ; Braga, C.L. ; Silva, J.S. ; Samary, C.S. ; Vieira, J.B. ; Cruz, F. ; Rocha, N.N. ; Sudo, G.Z. ; Rocco, P.R.M. ; Silva, P.L.  Effects of infigratinib, new fibroblast growth factor receptor-1 inhibitor, with or without sildenafil in experimental pulmonary arterial hypertension. British journal of pharmacology , v. 1, p. `1, 2019.

 

Doi: 10.1111/bph.14807

 

Alves, B.E.O. ; Alencar, A.K.N. ; Gamba, L.E.R. ; Trachez, M.M.. ; Silva, J.S. ; Araújo, J.S.C. ; Montagnoli, T.L. ; Mendes, L.V.P. ; Coelho, P.M.P. ; Cunha, V.M.N. ; Otero, R.M.; Oliveira, G.M.M. ; Lima, L.M. ; Barreiro, E.J. ; sudo, roberto t. ; Sudo, G.Z . Reduction of cardiac and renal dysfunction by new inhibitor of dpp4 in diabetic rats. Pharmacological reports , v. 1, p. 1, 2019.

 

Doi:10.1016/j.pharep.2019.07.005

Barbosa, J. N. ; Hernandez, R. A.; Barros, E.O. ; Branco, L. A. C. ; Feijo, P. R. O. ; Romeiro, L. A. S. ; Nasciutti, L. E. ; Noël, F.G. ; Sainz, J. A.G.; Silva, C. L. M.  The α1-adrenoceptor-mediated human hyperplastic prostate cells proliferation is impaired by egf receptor inhibition. Life sciences , v. 239, p. 117048, 2019.


Doi: 10.1016/j.lfs.2019.117048

Dias, F.C. ; Alves, V.S. ; Matias, D.O. ; Figueiredo, C.P. ; Miranda, A.L.P. ; Passos, G.F. ; Costa, R . The selective trpv4 channel antagonist hc-067047 attenuates mechanical allodynia in diabetic mice. European journal of pharmacology, v. 856, p. 172408, 2019.

Doi: 10.1016/j.ejphar.2019.172408

Silva, R. C. ; Veiga, F. ; Vilela, F.C. ; Pereira, A.V. ; Cunha,T.T.S, ; Tesch, R ; Viegas, C. ; Dias, D.F. ; Giusti-paiva, Alexandre ; Veloso, M.P.; Fraga, C.A.M . Design, synthesis and pharmacological evaluation of novel anti-inflammatory and analgesic o-benzyloxime compounds derived from natural eugenol. Letters in drug design & discovery, v. 15, p. 1157-1166, 2019.

 

Doi : 10.2174/1570180815666180620145609

Silva, R.R ; Silva, L. T. P. ; Pompeu, T. E.T. ; Duarte, D.A. ; Fraga, C. A.M. ; Barreiro, E. J. ; Menegatti,  R; Costa-neto,C. M. ; Noël, F . Evaluation of functional selectivity of haloperidol, clozapine, and lassbio-579, an experimental compound with antipsychotic-like actions in rodents, at g protein and arrestin signaling downstream of the dopamine d2 receptor. Frontiers in pharmacology, v. 10, p. 628, 2019.

 

Doi: 10.3389/fphar.2019.00628

Rodrigues, D.A. ; Sagrillo, F.S . ; Fraga, C.A. M.  Duvelisib: a 2018 novel fda-approved small molecule inhibiting phosphoinositide 3-kinases. Pharmaceuticals, v. 12, p. 69, 2019.

 

Doi:10.3390/ph12020069

Monteiro, C.E.S. ; Franco, A.X. ; Sousa, J.A.O. ; Matos, V.E.A. ; Souza, E.P. ; Fraga, C.A.M.; Barreiro, E.J. ; Souza, M.H.L.P. ; Soares, P.M.G. ; Barbosa, A.L.R . Gastroprotective effects of n-acylarylhydrazone derivatives on ethanol-induced gastric lesions in mice are dependent on the no/cgmp/katp pathway. Biochemical pharmacology, v. 169, p. 113629, 2019.

 

Doi: 10.1016/j.bcp.2019.113629

 

Pinheiro, P.S. M.; Rodrigues, D.A. ; Maia, R. C. ; Thota, S ; Fraga, C. A. M. The use of conformational restriction in medicinal chemistry. Current topics in medicinal chemistry, v. 19, p. 1712-1733, 2019.

 

Doi: 10.2174/1568026619666190712205025

Fraga, C.A.M. Strategies and tactics in medicinal chemistry. Current topics in medicinal chemistry, v. 19, p. 1677-1678, 2019.

 

Doi : 10.2174/156802661919191021122941

 

Predes, D. ; Oliveira, L. F. S. ; Ferreira, L. S. S. ; Maia, L.A.. ; Delou, J.M. A. ; Faletti, A ; Oliveira, I. ; Amado, N.G. ; Reis, A.H. ; Fraga, C.A. M. ; Kuster, R. ; Mendes, F.A. ; Borges, H. l. ; Abreu, J.G. The chalcone lonchocarpin inhibits wnt/β-catenin signaling and suppresses colorectal cancer proliferation. Cancers, v. 11, p. 1968, 2019.

 

Doi: 10.3390/cancers11121968

Oliveira, S. D. S. ; Chen,J. ; Castellon, M. ; Mao, M. ; Raj,J. U. ; Comhair, S. ; Erzurum, S. ; Silva, C.L.M ; Machado, R. F. ; Bonini, M. G. ; Minshall, R.  Injury-induced shedding of extracellular vesicles depletes endothelial cells of cav-1 (caveolin-1) and enables tgf-β (transforming growth factor-β)-dependent pulmonary arterial hypertension. Arteriosclerosis thrombosis and vascular biology , v. 39, p. 1, 2019.

 

Doi:10.1161/atvbaha.118.312038

 

Chaves, M. M. ; Sinflorio, D. A. ; Thorstenberg, M. L. ; Martins, M. D. A. ; Souza, A. C. A.M. ; Rangel, T. P. ; Silva, C.L.M. ; Bellio, M. ; Canetti, C. ; Silva, R.C. Non-canonical nlrp3 inflammasome activation and il-1β signaling are necessary to l. Amazonensis control mediated by p2x7 receptor and leukotriene b4. Plos pathogens , v. 15, p. E1007887, 2019.

 

Doi:10.1371/journal.ppat.1007887

 

Quaresma, B.M.C.S. ; Pimenta, A.R. ; Silva, A.C.S ; Pupo, A.S. ; Romeiro, L.A.S. ; Silva, C.L.M ; Noel, F.G . Revisiting the pharmacodynamics uroselectivity of alpha1-adrenergic receptor antagonists. Journal of pharmacology and experimental therapeutics , v. 270, p. Jpet.119.260216, 2019.

 

Doi:10.1124/jpet.119.260216

Amaral, D.N.; Lategahn,J. ; Fokoue, H.H. ; Silva, E.M.B. ; Sant’anna, C.M.R. ; Rauh, D. ; Barreiro, E.J.. ; Laufer, S. ; Lima, L.M . A novel scaffold for egfr inhibition: introducing n-(3-(3-phenylureido)quinoxalin-6-yl) acrylamide derivatives. Scientific reports , v. 9, p. 1-12, 2019.

 

Doi:10.1038/s41598-018-36846-7

Queiroz, A.C. ; Alves, M.A. ; Barreiro, E.J. ; Lima, L.M. ; Moreira, M.S.A . Semicarbazone derivatives as promising therapeutic alternatives in leishmaniasis. Experimental parasitology , v. 201, p. 57-66, 2019.

 

Doi:10.1016/j.exppara.2019.04.003

 

Barreiro, E.J. What is hidden in the biodiversity? The role of natural products and medicinal chemistry in the drug discovery process. Anais da academia brasileira de ciências (online) , v. 91, p. E20190306-e20190306, 2019.

 

Doi:10.1590/0001-3765201920190306 

Camaforte, N.A. P. ; Saldanha, L.L. ; Vareda, P. M. P. ; Neto, J.M.R. ; Senger, M.R. ; Delgado, A.Q.; Morgan, H. J. N. ; Violato, N. M. ; Pieroni, L.G. ; Dokkedal, A.L. ; Júnior, F.P.S. ; Bosqueiro, J.R. Hypoglycaemic activity of bauhinia holophylla through gsk3-β inhibition and glycogenesis activation. Pharmaceutical biology , v. 57, p. 269-279, 2019.

 

Doi: 10.1080/13880209.2019.1599962

 

Merigueti, T. ; Carneiro, M. W. ; Assef, A. P. D. C. ; Júnior, F.P.S. ; Silva, F. A. B.  Findtargetsweb: a user-friendly tool for identification of potential therapeutic targets in metabolic networks of bacteria. Frontiers in genetics , v. 10, p. 1-14, 2019.

 

Doi: 10.3389/fgene.2019.00633

 

Pereyra, C.E. ; Dantas, R.F. ; Ferreira, S.B. ; Gomes, L.P. ; Júnior, F.PS.  The diverse mechanisms and anticancer potential of naphthoquinones. Cancer cell international , v. 19, p. 1-20, 2019.

 

Doi:10.1186/s12935-019-0925

 

Dantas, R.F. ; Senger, M.R. ; Cardoso, M.F. C. ; Ferreira, V.F. ; Souza, M.C. B. V. ; Silva, F.C. ; Jùnior, F.P.S.  Screening of 1,2-furanonaphthoquinones 1,2,3-1h-triazoles for glycosidases inhibitory activity and free radical scavenging potential: an insight in anticancer activity. Medicinal chemistry research , v. 28, p. 1579-1588, 2019.

 

Doi:10.1007/s00044-019-02396-4

 

Dantas, R.F. ; Evangelista, T.C.S. ; Neves, B.J. ; Senger, M.R. ; Andrade, C.H. ; Ferreira, S.B. ; Junior, F.P.S . Dealing with frequent hitters in drug discovery: a multidisciplinary view on the issue of filtering compounds on biological screenings. Expert opinion on drug discovery , p. 1-14, 2019.

 

Doi: 10.1080/17460441.2019.1654453

Torres, P.H. M. ; Sodero, A.C. R. ; Jofily, P. ; Jùnior, F.P.S. Key topics in molecular docking for drug design. International journal of molecular sciences , v. 20, p. 4574, 2019.

 

Doi: 10.3390/ijms20184574

 

Lopes, J.P.B. ; Silva, L. ; Ceschi, M.A. ; Lüdtke, D.S. ; Zimmer, A.R. ; Ruaro, T.C. ; Dantas, R.F. ; Salles, C.M.C. ; Júnior, F.P.S. ; Senger,M.R. ; Barbosa, G. ; Lima, L.M. ; Guedes, I.A. ; Dardenne, L.E . Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling. Medchemcomm , p. 99, 2019.

 

Doi:10.1039/c9md00358d

Neves, G.; Grace, A. A.  Α7 nicotinic receptor full agonist reverse basolateral amygdala hyperactivity and attenuation of dopaminergic neuron activity in rats exposed to chronic mild stress. European neuropsychopharmacology , v. 10/12, p. 1, 2019.

Doi: 10.1016/j.euroneuro.2019.09.009

Monteiro, J. ; Lemos, G.A. ; Ferreira, E.S. ; Marques, A. M. ; Neves, G. ; Silveira, M. S. ; Galina, A.  Energization by multiple substrates and calcium challenge reveal dysfunctions in brain mitochondria in a model related to acute psychosis. Journal of bioenergetics and biomembranes , v. 1, p. 1, 2019.

Doi: 10.1007/s10863-019-09816-5

Akuthota, P. ; Neves, J.S. ; Ueki, S . Editorial: severe eosinophilic disorders: mechanisms and clinical management. Frontiers in immunology , v. 10, 2019.

Neto, F.M. ; Matos, M.S. ; Costa, A.C.R. ; Reis, R.A.M. ; Atella, G.C. ; Alves, L.M. ; Carvalho, D.P. ; Ketzer, L.A. ; Costa, V.M.C . Brown adipose tissue remodeling induced by corticosterone in wistar male rats. Experimental physiology , v. 104, p. 514-528, 2019.

 

Doi: 10.1113/ep087332

 

Portovedo, S. ; Gaido, N. ; Nunes, B. ; Nascimento, A. G. ; Rocha, A. ; Magalhaes, M. ; Nascimento, G. ; Carvalho, D.P. ; Soares, P. ; Takiya, C. ; Faria, M. S. ; Alves, L.M . Differential expression of hmga1 and hmga2 in pituitary neuroendocrine tumors. Molecular and cellular endocrinology , v. 19, p. 30110-30118, 2019.

 

Doi:10.1016/j.mce.2019.04.010

 

Silva, M.M. ; Gonçalves, C.F.L. ; Alves, L.M. ; Fortunato, R.S. ; Carvalho, D.P. ; Ferreira, A.C.F . Inhibition of type 1 iodothyronine deiodinase by bisphenol a. Hormone and metabolic research , v. 51, p. 671-677, 2019.

 

Doi: 10.1055/a-0919-3879

 

Costa, C. S. ; Alves, L.M. ; Merrill, M. A. L. ; Silva, L. V. ; Graceli, J. B.  The tributyltin leads to obesogenic mammary gland abnormalities in adult female rats. Toxicology letters , v. 307, p. 59-71, 2019.

 

Doi: 10.1016/j.toxlet.2019.02.016

Lima, L.M.Alves, M.A. ; Amaral, D.N . Homologation: a versatile molecular modification strategy to drug discovery. Current topics in medicinal chemistry , v. 19, p. 1-17, 2019.

 

Doi : 10.2174/1568026619666190808145235

Gonsalez, S.R. ; Cortês, A.L. ; Silva, R.C. ; Lowe,J. ; Prieto, M.C. ; Lara, L.S . Acute kidney injury overview: from basic findings to new prevention and therapy strategies. Pharmacology & therapeutics , v. 200, p. 1-12, 2019.

 

Doi: 10.1016/j.pharmthera.2019.04.001

Pereira, D. G. ; Rendeiro, M. M. ; Cortes, V. F. ; Barbosa, L.A. ; Quintas, L. E. M. . Antagonistic anticancer effect of paclitaxel and digoxin combination. Journal of cellular biochemistry , v. 1, p. 1, 2019.

 

Doi:10.1002/jcb.28583

 

Carvalho, D. C. M. ; Silva, L. H. C. ; Lima, E. A. ; Galvao, J. ; Alves, A. ; Feijo, P.R. ; Quintas, L. E. M. ; Mascarenhas, S. . Marinobufagenin inhibits neutrophil migration and proinflammatory cytokines. Journal of immunology research , v. 2019, p. 1-11, 2019.

 

Doi:10.1155/2019/1094520

 

Bastos, U. M. C. ; Rosa, I. A. ; Teixeira, J. D. ; Santos, G. G. ; Costa, M. L. ; Quintas, L. E. M. ; Mermelstein, C.  Isoproterenol induces an increase in muscle fiber size by the proliferation of pax7 positive cells and in a mtor independent mechanism. Cell biology international , v. 1, p. 1-10, 2019.

 

Doi:10.1002/cbin.11190

Chater, J.M. ; Mathon, C. ; Larive, C.K. ; Merhaut, D.J. ; Tinoco, L.W. ; Mauk, P.A. ; Jia, Z. ; Preece, J.E.  Juice quality traits, potassium content, and 1h nmr derived metabolites of 14 pomegranate cultivars. Journal of berry research, v. 9, p. 1-17, 2019.

 

Doi: 10.3233/jbr-180344

Nirma, C.; Rangel, G.T. ; Alves, M.A. ; Casanova,L.M. ; Moreira, M.M. ; Rodrigues, L.M.; Hamerski, L. ; Tinoco, L.W . New nucleoside hydrolase inhibitors from brazilian flora. Rsc advances , v. 9, p. 18663-18669, 2019.


Doi: 10.1039/c9ra02382h

Figueiredo, C. P. ; Aragao, F. G. Q.B. ; Neris, R. L. S. ; Frost, P. S. ; Mello, C. S. P. S. ; Souza, I. N. O. ; Zeidler, J. D. ; Zamberlan, D. C. ; Sousa, V. L. ; Souza, A. S. ; Guimaraes, A. L. A. ; Bellio, M. ; Souza, J. M. ; Leon, S. V.A. ; Neves, G.A. ; Neto, H. A.P. ; Castro,N.G.; Felice, F. G. ; Miranda, I.A. ; Clarke, J. R. ; Poian, A. T. ; Ferreira, S. T.  Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice. Nature communications, v. 10, p. 3890, 2019.

Doi:10.1038/s41467-019-11866-7

Menezes, A. C. ; Reis, G. H. ; Nunes, M. C.O. ; Mariath, F. ; Cabanel, M. ;Pontes, B. ; Castro, N. G. ; Neto, J. M.B. ; Carneiro, K.  Live cell imaging supports a key role for histone deacetylase as a molecular target during glioblastoma malignancy downgrade through tumor competence modulation. Journal of oncology, v. 2019, p. 1-16, 2019.

Doi:10.1155/2019/9043675

Freitas, C.S. Higa, L.M. Sacramento, C.Q. Ferreira, A.C. Reis,P.A. Delvecchio, R.M., Fabio , L. Lima, G.J.W.B., Vieira, Y.R.M.H., Rocha, N.H.M., Leme, R.P.P.B.L.V.B., Mônica M. L. Rodrigues, G.O.M. Lopes, C.E.Q.J. Lima,C.M. Costa, V.V. Teixeira, M.M.. Bozza, F.A.. Bozza, P.T. Boechat, N.T. Amilcar. Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo. Plos neglected tropical diseases , v. 13, p. E0007072, 2019.

Doi:10.1371/journal.pntd.0007072

 

Silva, R.M.R.J. ; Gandi,M.O. ; Mendonça,J.S. ; Carvalho,A.S. ; Coutinho,J.P.; Aguiar, A.C.C.; Krettli,A.U. ; Boechat,N . New hybrid trifluoromethylquinolines as antiplasmodium agents. Bioorganic & medicinal chemistry , v. 27, p. 1002-1008, 2019.

Doi: 10.1016/j.bmc.2019.01.044

Gonzaga, D. T. G. ; Oliveira, F. H. ; Salles, J. P. ; Bello, M. L. ; Rodrigues, C. R. ; Castro, H. C. ; Souza, H. ; Reis, C. ;Leme, R. ; Mafra, J. C. M. ; Pinheiro, L.C.S. ; Boechat, N. ; Faria, R. X.  Synthesis, biological evaluation, and molecular modeling studies of new thiadiazole derivatives as potent p2x7 receptor inhibitors. Frontiers in chemistry , v. 7, p. 1-15, 2019.

Doi:10.3389/fchem.2019.00261

45. Ferreira, A.C. ; Reis, P.A. ; Freitas, C.S. ; Sacramento, C.Q. ; Hoelz, L.V.B. ; Bastos, M.M. ; Mattos, M ; Rocha, N ; Quintanilha, I.G.A. ; Pedrosa, C.S.G. ; Souza, L.R.Q. ; Loiola, E.C. ; Trindade, P.; Vieira, Y.R. ; Lima, G.B. ; Neto,H.C.C.F.; Boechat,N. ; Rehen,S.K. ; Brüning,K.; Bozza,F.A. ; Bozza,P.T. ; Souza,T.M.L.  Beyond members of the flaviviridae family, sofosbuvir also inhibits chikungunya virus replication. Antimicrobial agents and chemotherapy (online) , v. 63, p. E01389-18, 2019.

Doi: 10.1128/aac.01389-18

Venâncio, T.; Oliveira,L.M.; Pawlak, T.; Ellena, J.; Boechat,N. ; Brown,S.P.  The use of variable temperature 13 c solid-state mas nmr and gipaw dft calculations to explore the dynamics of diethylcarbamazine citrate. Magnetic resonance in chemistry , v. 57, p. 200-208, 2019.

Doi:10.1002/mrc.4790

Lima,D.A.; Andreotti, C.E.A.; Ferreira, F.A. ; Pauli,K.B.; Silva,G.R.; Ribeiro,R.C.L. ; Dalsenter,P.R.; Boechat,N. ; Junior, G.A. ; Lourenço,E.L.B.; Lívero,F.A.R. Safety assessment of mefas: an innovative hybrid salt of mefloquine and artesunate for malaria treatment. Drug and chemical toxicology , v. 42, p. 1-6, 2019.

Doi: 10.1080/01480545.2019.1607371

Feitosa,L.M. ; Silva,E.R. ; Hoelz,L.V.B.; Souza,D.L. ; Come, J.A.A.S.S.; Santos, C.C. ; Batista,M.M. ; Soeiro,M.N.C. ; Boechat,N. ; Pinheiro,L.C.S.  New pyrazolopyrimidine derivatives as leishmania amazonensis arginase inhibitors. Bioorganic & medicinal chemistry, v. 27, p. 3061-3069, 2019.

Doi: 10.1016/j.bmc.2019.05.026

Silva, M. R.S. ; Araújo, J. S. ; Peres, R. B. ; Silva, P. B. ; Batista, M. M. ; Azevedo, L. D. ; Bastos, M. M. ; Bahia, M. T. ; Boechat, N. ; Soeiro, M. N. C. Repurposing strategies for chagas disease therapy: the effect of imatinib and derivatives against trypanosoma cruzi. Parasitology , v. 146, p. 1-7, 2019.

Doi: 10.1017/s0031182019000234.

Trompowsky, A.C.M.V.  ; Conde, T.R. ; Lemos, R.C. ; Quaresma, B.M.C.S ; Pitombeira, M.C.R.S. ; Carvalho, A.S. ; Boechat, N. ; Salomão,K ; Castro, S.L. ; Zamith, H.P.S . In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents. Memórias do instituto oswaldo cruz , v. 114, p. 1-10, 2019.

Doi: 10.1590/0074-02760190017


Pinheiro, L.C.S ; Ferreira, M.L.G. ; Silveira, F.F. ; Feitosa, L.M. ; Boechat, N . Synthetic compounds with sulfonamide moiety against leishmaniasis: an overview. Medicinal chemistry research , v. 28, p. 1807-1817, 2019.

Doi:10.1007/s00044-019-02432-3

Lima, E.C. ; Castelo-branco, F.S. ; Maquiaveli, C.C. ; Farias, A.B. ; Rennó, M.N. ; Boechat, N. ; Silva, E.R.  Phenylhydrazides as inhibitors of leishmania amazonensis arginase and antileishmanial activity. Bioorganic & medicinal chemistry, v. 27, p. 3853-3859, 2019.

Doi:10.1016/j.bmc.2019.07.022
 

C. S. Pinheiro, luiz ; Lívia, M.F. ; Gandi, M.O. ; Silveira, F.F. ; Boechat, N. The development of novel compounds against malaria: quinolines, triazolpyridines, pyrazolopyridines and pyrazolopyrimidines. Molecules , v. 24, p. 4095, 2019.

Doi:10.3390/molecules24224095

Vale, C.M.F. ; Quaresma, B.M.S ; Pitombeira, M.C.R. ; Brito, M.A. ; Farias, P.P.; Castro, S.L. ; Salomão, K. Carvalho, A.S. ; Paula, J.I.O. ; Nascimento, S.B. ; Cupello, M.P. ; Paes, M.C.; Boechat, N. ; Felzenszwalb, I . Novel nitroimidazole derivatives evaluated for their trypanocidal, cytotoxic, and genotoxic activities. European journal of medicinal chemistry , v. 2019, p. 111887-111902, 2019.

Doi: 10.1016/j.ejmech.2019.111887.

Boechat, núbia amagalhães j.l. ; zulmira hartz ; marlede menezes ; mendonça, jorge s.  An overview of antibiotics in brazil:a sovereign been lost of the amoxicillin. Chimica oggi-chemistry today , v. 37, p. 73, 2019.

Trompowsky, A.C.M.V.  ; Conde, T.R. ; Lemos, R.C. ; Quaresma, B.M.C.S ; Pitombeira, M.C.R.S. ; Carvalho, A.S. ; Boechat, N. ; Salomão,K ; Castro, S.L. ; Zamith, H.P.S . In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents. Memórias do instituto oswaldo cruz , v. 114, p. 1-10, 2019.

Doi: 10.1590/0074-02760190017

Soares, S.S. ; Bekbolatova,E. ; Cotrim, M.D. ; Sakipova, Z. ; Ibragimova, L.; Koch,W.K. ; Giorno, T.B.S. ; Fernandes, P.D. ; Fonseca, D.A. ; Boylan, F.  Chemistry and pharmacology of the kazakh crataegus almaatensis pojark: an asian herbal medicine. Antioxidants, v. 8, p. 300, 2019.

Doi: 10.3390/antiox8080300

Giorno, T.B.S. ; Santos, C.H.C. ; Carvalho, M.G. ; Silva, V.C. ; Sousa, P.T. ; Fernandes, P.D. ; Boylan,F . Study on the antinociceptive activity and mechanism of action of isolated saponins from siolmatra brasiliensis (cogn.) Baill. Molecules , v. 24, p. 4584, 2019.

Doi: 10.3390/molecules24244584


Strauch, M.A. ; Tomaz, M.A. ; Machado, M.M. ; Cons, B.L.; Neto, F.C.P. ; Cruz, J.M.T. ; Henriques, M.S.T. ; Souza, P.D.N. ; Gomes, S.L.S. ; Costa, P.R.R. ; Schaeffer, E. ; Silva, A.J. M. ; Melo, P.A . Lapachol and synthetic derivatives: in vitro and in vivo activities against bothrops snake venoms. Plos one , v. 14, p. E0211229-18, 2019.

Doi: 10.1371/journal.pone.0211229.

Telles, T. S. ; Silva,P.M. ; Martins, M.A. ; Carvalho, V. Glucocorticoids decrease the numbers and activation of mast cells by inducing the transactivation receptors of ages. Journal of leukocyte biology, v. 2018, p. 1-12, 2019.

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Rumjanek, V. M ; Maia, R.C. ; Salustiano, E.J. ; Costa, P.R.R . Insights into the biological evaluation of pterocarpanquinones and carbapterocarpans with anti-tumor activity against mdr leukemias. Anti-cancer agents in medicinal chemistry , v. 18, 2019.

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Carvalho, V.F. ; Barreto, E.O. ; Arantes, A.C.S. ; Serra, M.F. ; Ferreira, T.P.T. ; Sá, Y.A.J. P. ; Hogaboam, C.M. ; Martins, M.A. ; Silva, P.M. R. Diabetes downregulates allergen-induced airway inflammation in mice. Mediators of inflammation , v. 2018, p. 1-11, 2018.

 

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Bastos, I. ; Pinheiro, P. ; Costa, F. ; Rocha,M. ; Sant’anna, C. ; Braz, D.; Souza, E. ; Martins, M.A. ; Barreiro, E.J. ; Ferreira, F. ; Barroso, R. ; Fraga, C.  Design, synthesis, experimental and theoretical characterization of a new multitarget 2-thienyl-n-acylhydrazone derivative. Pharmaceuticals, v. 11, p. 119-14, 2018.

 

Doi:10.3390/ph11040119

Serra, M.F. ; Cotias, A.C. ; Pão, C.R. R. ; Daleprane, J.B. ; Jurgilas, P.B. ; Couto, G.C. ; Valotta, E.A.A. ; Cordeiro, R.S. B. ; Carvalho, V.F. ; Silva, P.M. R. ; Martins, M.A.  Repeated allergen exposure in a/j mice causes steroid-insensitive asthma via a defect in glucocorticoid receptor bioavailability. Journal of immunology , v. 201, p. Ji1700933-860, 2018.

 

Doi: 10.4049/jimmunol.1700933

Viegas, F.P.F.S.D., Rocha, M.C.M.D., Riquiel, M.M.M.M.R., Vaz, S.M.S.L.R.P., Mancini, L.M. Oliveira,K.C.M. Morais,P.C.;Gontijo,E.P.; Silva,V.S.; Motta,F.;  Peçanha,D.F.; Castro, D.; Gonçalves, N.; Neves, G.A.;  Paiva,G.; Vilela,A. Orlandi,F.C. Camps, L.; ihosvany veloso,  Coelho,M.P.L.  Ionta,L.F. Silva, M.F. Pereira,G.A. Machado ,R. Design, synthesis and pharmacological evaluation of n -benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: discovery of novel multi-target anti-alzheimer prototype drug candidates. European journal of medicinal chemistry, v. 147, p. 48-65, 2018.

Doi:10.1016/j.ejmech.2018.01.066

Guimarães, M.Z. P. ; Vecchi, R.; Vitória, G.; Sochacki,J.K. ; Paulsen,B.S. ; Lima, I.; Silva, F.R. ; Costa, R.F. M. ; Castro,N.G. ; Breton, L.; Rehen,S.K.  Generation of ipsc-derived human peripheral sensory neurons releasing substance p elicited by trpv1 agonists. Frontiers in molecular neuroscience, v. 11, p. 1-17, 2018.

Doi:10.3389/fnmol.2018.00277

Branco, F.S.C. ; Lima, E.C. ; Domingos, J.L.O.; Pinto, A.C. ; Lourenço, M.C.S. ; Gomes, K.M. ; Lima, M.M.C. ; Lima, C.F.A. ; Aiub, C.A.F. ; Felzenszwalb, I. ; Costa, T.E.M.M. ; Penido, C. ; Henriques, M.G. ; Boechat,N. . New hydrazides derivatives of isoniazid against mycobacterium tuberculosis: higher potency and lower hepatocytotoxicity. European journal of medicinal chemistry, v. 146, p. 529-540, 2018.

Doi: 10.1016/j.ejmech.2018.01.071

Leite, D.I. ; Fontes,F.V. ; Bastos, M.M. ; Hoelz, L.V.B. ; BiancoM.C.A.D. ; Oliveira, A.P. ; Silva, P.B. ; Silva, C.F. ; Batista, D.G.J. ; Gama, A.N.S. ; Peres, R.B. ; VillarJ.D.F. ; Soeiro, M.N.C.; Boechat, N.  New 1,2,3-triazole-based analogues of benznidazole for use against trypanosoma cruzi infection: in vitro and in vivo evaluations. Chemical biology & drug design , v. 2018, p. 1-7, 2018.

Doi: 10.1111/cbdd.13333.

Boechat, N.; Pinheiro, L.C.S. ; Feitosa, L. M. ; Silveira, F. F. Current antimalarial therapies and advances in the development of semi-synthetic artemisinin derivatives. Anais da academia brasileira de ciências (online) , v. 90, p. 1251-1271, 2018.

Doi:10.1590/0001-3765201820170830.


Silveira, F.F.; Feitosa, L.M. ; Mafra, J.C. M. ; Ferreira,M.L.G. ; Rogerio, K.R. ; Carvalho, L.J. M. ; Boechat, N. ; Pinheiro, L.C. S.  Synthesis and anti-plasmodium falciparum evaluation of novel pyrazolopyrimidine derivatives. Medicinal chemistry research, v. 27, p. 1876-1884, 2018.

Doi:10.1007/s00044-018-2199-4

 

Hoelz, L.V.B. ; Calil, F.A. ; Nonato, M.C. ; Pinheiro, L.C.S. ; Boechat, N. Plasmodium falciparum dihydroorotate dehydrogenase: a drug target against malaria. Future medicinal chemistry , v. 10, p. 1853-1874, 2018.

Doi: 10.4155/fmc-2017-0250.

Costa, C.C.P. ; Boechat, N. ; Bastos, M.M. ; Silva, F.C. ; Marttorelli, A. ; Souza, T.M.L. ; Baptista, M.S.. ; Hoelz, L.V.B. ; Cafffarena, E.R . New efavirenz derivatives and 1,2,3-triazolyl-phosphonates as inhibitors of reverse transcriptase of hiv-1. Current topics in medicinal chemistry, v. 18, p. 1494-1505, 2018.

Doi: 10.2174/1568026618666181029150118.

Giorno, T.B.S. ; Moreira, I.G.S. ; Rezende, C.M. ; Fernandes, P.D . New βn-octadecanoyl-5-hydroxytryptamide: antinociceptive effect and possible mechanism of action in mice. Scientific reports , v. 8, p. 10027, 2018.

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Santos, C.C.S. ; Guilhon, C.C. ; Moreno, D.S.A. ; Alviano, C.S. ; Estevam, C.S. ; Blank,A.F. ; Fernandes, P.D . Anti-inflammatory, antinociceptive and antioxidant properties of schinopsis brasiliensis bark. Journal of ethnopharmacology , v. 213, p. 176-182, 2018.

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Cortes, A.L. ; Gonsalez, S.R. ; Rioja, L.S. ; Oliveira, S.S.C. ; Santos, A.L.S. ; Prieto, M. C. ; Melo, P.A. ; Lara, L.S. Protective outcomes of low-dose doxycycline on renal function of wistar rats subjected to acute ischemia/reperfusion injury. Biochimica et biophysica acta-molecular basis of disease , v. 1864, p. 102-114, 2018.

Doi:10.1016/j.bbadis.2017.10.005


Strauch, M.A. ; Souza, G.J. ; Pereira, J.N. ; Ramos, T.S. ; Cesar, M.O. ; Tomaz, M.A.; Machado, M.M.S.; Neto, F.C.P. ; Melo, P.A. True or false coral snake: is it worth the risk? A micrurus corallinus case report. Journal of venomous animals and toxins including tropical diseases , v. 24, p. 10, 2018.

Doi:10.1186/s40409-018-0148-9

Nunes, C. F. C. G. ; Nogueira , J.S.; Canto, F.B. ; Vianna, P. H. O. ; Bt, C.; Silva,P.M. R. ; Rodrigues, K. ; Pillotto, R. M. ; Busch, M. ; Atella, G. C. ; Vale, A. ; Bellio, M. ; Nobrega, A. ; Fucs, R.  Probiotic treatment during neonatal age provides optimal protection against experimental asthma through modulation of microbiota and regulatory t cells. International immunology,  2018.

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2022

de Almeida, Lana R.; Alves, Marina A.; Mastella, Ana M. O.; Garret, Rafael; Pereira, Maria J. R.. Neotropical mustelids: fecal metabolome diversity and its potential for taxonomic discrimination. Integrative Zoology, 2022.

Doi: 10.1111/1749-4877.12645

Amorim, Carolinne S.; Moraes, João A.; Magdalena, Ingrid J.; López, Sheila G.; Carneiro, Ana C. D.; Nunes, Isabelle K. C.; Pizzatti, Luciana; Sardela, Vinícius, F.; Neto, Aquino F. R.; Mirotti, Luciana C.; Pereira, Henrique M. G.; Renovato-Martins, Mariana. Extracellular Vesicles From Stored Red Blood Cells Convey Heme and Induce Spic Expression on Human Monocytes. Frontiers in Immunology, v. 13, p. 1, 2022.

Doi: 10.3389/fimmu.2022.833286

Amorim, Carolinne S.; Docasar, Clara L.; Guimarães-Bastos, Daniel; Frony, Ana C.; Barja-Fidalgo, Christina; Renovato-Martins, Mariana; Moraes, João A.. Extracellular Vesicles Derived from MDA-MB-231 Cells Trigger Neutrophils to a Pro-Tumor Profile. Cells, v. 11, p. 1875, 2022.

Doi: 10.3390/cells11121875

Andrade, Marcelle N.; Melo-Paiva, Francisca; Teixeira, Mariana P.; de Lima-Junior, Nieldson C.; Soares, Paula; Graceli, Jones B.; de Carvalho, Denise P.; Morris, Eduardo A. R.; Ferreira, Andrea C. F.; Miranda-Alves, Leandro. Environmentally relevant dose of the endocrine disruptor tributyltin disturbs redox balance in female thyroid gland. Molecular and Cellular Endocrinology, v. 553, p. 111689, 2022.

Doi: 10.1016/j.mce.2022.111689

Barbosa, G.; Gelves, Luis G. V.; Costa, Caroline M. X.; Franco, Lucas S.; De Lima, João A. L.; Aparecida-Silva, Cristiane; Teixeira, John D.; Mermelstein, Cláudia S.; Barreiro, Eliezer J.; Lima, Lídia M.. Discovery of Putative Dual Inhibitor of Tubulin and EGFR by Phenotypic Approach on LASSBio-1586 Homologs. Pharmaceuticals, v. 15(8), p. 1-22, 2022.

Doi: //doi.org/10.3390/ph15080913

Brasiel, Poliana G. A.; Guimarães, Fernanda V.; e Silva, Patricia M. R.; Bou-Habib, Dumith C.; Carvalho, Vinicius F.. Therapeutic Efficacy of Flavonoids in Allergies: A Systematic Review of Randomized Controlled Trials. Journal of Immunology Research, v. 2022, 2022.

Doi: 10.1155/2022/8191253

Cardoso, Tassya C.; Rocha, Marianna A.; Monteiro, Matheus M. L. V.; Alves, Vinícius S.; Savio, Luiz E. B.; Silva, Cláudia L. M.. The blockage of downstream P2Y2 receptor signaling inhibits the prostate cancer cell adhesion to endothelial cells. Life Sciences, v. 306(1), p. 120793, 2022.

Doi: 10.1016/j.lfs.2022.120793

Costa, Bianca; Corrêa, Luana B.; e Silva, Patricia M. R.; de Sá, Yago A. P. J.; Guimarães, Fernanda V.; Alencar, Luciana M. R.; Simões, Rafael L. Helal-Neto, Edward; Ricci-Júnior, Eduardo; Henriques, Maria G. M. O.; Rosas, Elaine C.; Santos-Oliveira, Ralph. Using pure Fucoidan and radiolabeled Fucoidan (99mTc-Fucoidan) as a new agent for inflammation diagnosis and therapy. Food Hydrocolloids for Health, v. 2, p. 10049, 2022.

Doi: 10.1016/j.fhfh.2021.100049

Caruso, Lucas ; Nadur, N. Fonseca ; Da Fonseca, M. Brandão ; Peixoto, De Almeida, Larissa; Lacerda, R. Barbosa; Graebin, C. Stephan; Kümmerle, Arthur Eugen. The Design of Multi-target Drugs to Treat Cardiovascular Diseases: Two(or more) Birds on One Stone. Current Topics in Medicinal Chemistry, v. 22, p. 366-394, 2022.

Doi:10.2174/1568026622666220201151248

Costa, Tamara G. F.; Oliveira, Marina M.; Toledo, Marina M.; Santos, Helio B.; Thome, Ralph G.; Cortes, Vanessa F.; Santos, Herica L.; Quintas, Luis E. M.; Fontes, Carlos F. L.; Barbosa, Leandro A.. Effect of Fe3+ on Na,K-ATPase: Unexpected activation of ATP hydrolysis. Biochimica et Biophysica Acta (BBA), v. 1864, p. 183868, 2022.

Doi: 10.1016/j.bbamem.2022.183868

Cunha, Thayssa T. S.; Silva, Rafaela R.; Rodrigues, Daniel A.; Pinheiro, Pedro S. M.; Kronenberger, T.; Sant’Anna, Carlos M. R.; Noël, François. Fraga, Carlos A. M.. Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted N-arylpiperazine Derivatives Characterized as D2/D3 Receptor Ligands, Candidates for the Treatment of Neurodegenerative Diseases. Biomolecules, v. 12(8), p. 1-18, 2022.

Doi: 10.3390/biom12081112 

Dantas, Rafael F.; Torres-Santos, Eduardo; Silva-Júnior, Floriano P.. Past and future of trypanosomatids high-throughput phenotypic screening. Mem Inst Oswaldo Cruz, v. 117, p. e210402, 2022.

Doi: 10.1590/0074-02760210402  

Faria, Jessica V.; Passos, Fernanda P.Z.; da Costa, Paulo H.A.; de Oliveira, Andressa P.; Cruz, Yasmin O.D. da; Castelo-Branco, Frederico S.; Lourenço, Maria C.S.; Murta, Silvane M.F.; Junior, Policarpo A.S.; Bernardino, Alice M.R.; Bastos, Monica M.; Boechat, Nubia. Novel 2-Nitroimidazole and Imidazooxazole Derivatives and their Activity against Trypanosoma cruzi and Mycobacterium tuberculosis. Medicinal Chemistry, v. 18, p. 701-709, 2022.

Doi: 10.2174/1573406418666211116144952

de Faria, Rachel A.; Oliveira, Pamella C. O.; de Carvalho, Mariana D. P.; Peixoto, Bruno S.; Severino, Vanessa G. P.; Tinoco, Luzineide W.; Rodrigues, Silvana V.; de Moraes, Marcela C.. High-resolution inhibition profiling and ligand fishing for screening of nucleoside hydrolase ligands in Moringa oleifera Lamarck. Journal of Pharmaceutical and Biomedical Analysis, v. 211, p. 114614, 2022.

Doi: 10.1016/j.jpba.2022.114614

França, Patrícia R. C.; Lontra, Anna C. P.; Fernandes, Patricia D.. Endometriosis: A Disease with Few Direct Treatment Options. Molecules, v. 27, p. 4034, 2022.

Doi: 10.3390/molecules27134034

Ferreira, Tatiana P. T.; Guimarães, Fernanda V.; Sá, Yago A. P. J.; Ribeiro, Natalia B. S.; de Arantes, Ana C. S.; Carvalho, Vinicius F.; Sousa, Lirlândia P.; Perretti, Mauro; Martins, Marcos A.; e Silva, Patricia M. R.. Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice. Cells, v. 11, p. 759, 2022.

Doi: 10.3390/cells11050759

Figueiredo-Junior, Alexsandro T.; Valença, Samuel S.; Fintonelli, Priscilla V.; dos Anjos, Francisca F.; de Brito-Gitirana, Lycia; Takiya, Christina M.; de Deus, Manuella L. D.. Treatment with Bixin-Loaded Polymeric Nanoparticles Prevents Cigarette Smoke-Induced Acute Lung Inflammation and Oxidative Stress in Mice. Antioxidants, v. 11, p. 1293, 2022.

Doi: 10.3390/antiox11071293

Gouvêa, Marcos M.; de Carvalho, Renata C.; Castelo-Branco, Frederico C.; Boechat, Nubia; Netto, Annibal D. P.; Marques, Flávia F. C.. The cleavage kinetics of hydrazide derivatives of isoniazid by HPLC-UV/DAD and its impact on activity against Mycobacterium tuberculosis.  Journal of Chromatography B, v. 1188, p. 123080, 2022.

Doi: 10.1016/j.jchromb.2021.123080

Lamichhane, Santosh; Sen, Partho; Dickens, Alex M.; Alves, Marina A.; Härkönen, Taina; Honkanen, Jarno; Vatanen, Tommi; Xavier, Ramnik J.; Hyötyläinen, Tuulia; Knip, Mikael; Orešič, Matej. Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes. Cell Reports Medicine, p. 100762, 2022.

Doi: 10.1016/j.xcrm.2022.100762

Lara, Lucienne S.; Gonzalez, Alexis A.; Hennrikus, Mathew T.; Prieto, Minofa C.. Hormone-dependent regulation of renin and effects on prorenin receptor signaling in the collecting duct. Current Hypertens Review, 2022.

Doi: 10.2174/1573402118666220216105357

Leite, Jacqueline A.; Pôças, Elisa; Maia, Gisele S.; Barbosa, Leandro; Quintas, Luis E. M.; Kawamoto, Elisa M.; da Silva, Maria L. C.; Scavone, Cristoforo; de Carvalho, Luciana E. D.. Effect of ouabain on calcium signaling in rodent brain: A systematic review of in vitro studies. Frontiers in Pharmacology, v. 13, p. 916312, 2022.

Doi: 10.3389/fphar.2022.916312

Leser, Felipe S.; Fiuza, Diogo N.; Miranda-Alves, Leandro. Importance of students congresses for medical training: A pioneer experience at Federal University of Rio de Janeiro. Revista Brasileira de Educação e Saúde-REBES, v. 11, p. 464-475, 2022.

Doi: 10.18378/rebes.v11i4.8632

Mansoldo, Felipe R. P.; Garrett, Rafael; Cardoso, Veronica S.; Alves, Marina A.; Vermelho, Alane B.. Metabology: Analysis of metabolomics data using community ecology tools. Analytica Chimica Acta, v. 1232, p. 340469, 2022.

Doi: 10.1016/j.aca.2022.340469

Mendes, Ana B. A.; Motta, Nadia A. V.; Lima, Gabriel F.; Autran, Lis J.; Brazão, Stephani C.; Magliano, D'Angelo C.; Sepúlveda-Fragoso, Vinícius; Scaramello, Christiane B. V.; Graceli, Jones B.; Miranda-Alves, Leandro; Brito, Fernanda C. F.. Evaluation of the effects produced by subacute tributyltin administration on vascular reactivity of male wistar rats. Toxicology, v. 465, p. 153067, 2022.

Doi: 10.1016/j.tox.2021.153067

Moreira, Lorrane K. S.; Silva, Rafaela R.; da Silva, Dayane M.; Mendes, Mirella A. S.; de Brito, Adriane F.; de Carvalho, Flávio S.; Sanz, Germán; Rodrigues, Marcella F.; da Silva, Artur C. G.; Thomaz, Douglas V.; de Oliveira, Valéria; Vaz, Boniek G.; Lião, Luciano M.; Valadares, Marize C.; Gil, Eric S.; Costa, Elson A.;  Noël, François; Menegatti, Ricardo. Anxiolytic- and antidepressant-like effects of new phenylpiperazine derivative LQFM005 and its hydroxylated metabolite in mice. Behavioural Brain Research, v. 417(24), p. 113582, 2022.

Doi: 10.1016/j.bbr.2021.113582

Nunes, Bruno; Pópulo, Helena; Lopes, José M.; Reis, Marta; Nascimento, Gilvan; Nascimento, Ana G.; Fernandes, Janaína; Faria, Manuel; de Carvalho, Denise P.; Soares, Paula; Miranda-Alves, Leaandro. Connexin Expression in Pituitary Adenomas and the Effects of Overexpression of Connexin 43 in Pituitary Tumor Cell Lines. Genes, v. 13, p. 674, 2022.

Doi: 10.3390/genes13040674

Oliveira, Andressa; Moura, Stefany; Pimentel, Luiz; Neto, João; Dantas, Rafael; Silva-Júnior, Floriano P.; Bastos, Monica; Boechat, Nubia. New Imatinib Derivatives with Antiproliferative Activity against A549 and K562 Cancer Cells. Molecules, v. 27(3), p. 750, 2022.

Doi: 10.3390/molecules27030750

Ortiz, Cindy J. C.; Silva, Matheus F.; Pruccoli, Letizia; Nadur, Nathália F.; De Azevedo, Luciana L.; Kümmerle, Arthur E.; Guedes, Isabella A.; Dardenne, Laurent E.; Coelho, Luiz F. L.; Guimarães, Marcos J.; Da Silva, Fernanda M. R.; Castro, Newton; Gontijo, Vanessa S.; Rojas, Viviana C. T.; De Oliveira, Merelym K.; Vitela, Fabiana C.; Giusti-Paiva, Alexandre; Barbosa, Gisele; Lima, Lídia M.; Pinheiro, Gabriel B.; Veras, Letícia G.; Mortari, Márcia R.; Tarozzi, Andrea; Júnior, Cláudio V.. Design, synthesis, and biological evaluation of new thalidomide–donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation. RSC Medicinal Chemistry, v. 13, p. 568-584, 2022.

Doi: 10.1039/D1MD00374G

Portovedo, Sérgio; Neto, Leonardo V.; Soares, Paula; de Carvalho, Denise P.; Takiya, Christina M.; Miranda-Alves, Leandro. Aggressive nonfunctioning pituitary neuroendocrine tumors. Brain Tumor Pathology, 2022.

Doi: 10.1007/s10014-022-00441-6

de Queiroz, Aline C.; Barbosa, G.; de Oliveira, Victória R. T.; Alves, Hélio M.; Alves, Marina A.; Carregaro, V.; da Silva, João S.; Barreiro, Eliezer J.; Alexandre-Moreira, Magna S.; Lima, Lídia M.. Pre-clinical evaluation of LASSBio-1491: From in vitro pharmacokinetic study to in vivo leishmanicidal activity. Plos One, v. 17(6), p. e0269447, 2022.

Doi: 10.1371/journal.pone.0269447

Rodrigues-Pereira, Paula; Andrade, Marcelle N.; Santos-Silva, Ana P.; Teixeira, Mariana P.; Soares, Paula; Graceli, Jones B.; de Carvalho, Denise P.; Dias, Glaecir R. M.; Ferreira, Andrea C. F.; Miranda-Alves, Leandro. Subacute and low-dose tributyltin exposure disturbs the mammalian hypothalamus-pituitary-thyroid axis in a sex-dependent manner. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, v. 254, p. 109279, 2022.

Doi: 10.1016/j.cbpc.2022.109279

Santos, Carine; Pimentel, Luiz; Cazian, Henayle; Oliveira, Andressa; Silva-Júnior, Floriano P.; Dantas, Rafael; Hoelz, Lucas; Marinho, Debora; Cunha, Anna; Bastos, Monica; Boechat, Nubia. Hybrids of Imatinib with Quinoline: Synthesis, Antimyeloproliferative Activity Evaluation, and Molecular Docking. Pharmaceuticals, v.15(3), p. 309, 2022.

Doi: 10.3390/ph15030309

Santos, Stephanie A. C. S.; Persechini, Pedro M.; Henrique-Santos, Bianca M.; Bello-Santos, Victória G.; Castro, Newton C.;  de Sousa, Júlia C.; Genta, Fernando A.; Santiago, Marcelo F.; Coutinho-Silva, Robson; Savio, Luiz E. B.; Kurtenbach, Eleonora. P2X7 Receptor Triggers Lysosomal Leakage Through Calcium Mobilization in a Mechanism Dependent on Pannexin-1 Hemichannels. Frontiers in Immunology, v. 13, p. 752105, 2022.

Doi: 10.3389/fimmu.2022.752105

Serra, Magda F.; Cotias, Amanda C.; Pimentel, Andreza S.; de Arantes, Ana C. S.; Pires, Ana L. A.; Lanzetti, Manuella; Hickmann, Jandir M.; Barreto, Emiliano; Carvalho, Vinicius F.; Silva, Patrícia M. R.; Cordeiro, Renato S. B.; Martins, Marco A.. Gold Nanoparticles Inhibit Steroid-Insensitive Asthma in Mice Preserving Histone Deacetylase 2 and NRF2 Pathways. v. 11, p. 1659, 2022.

Doi: 10.3390/antiox11091659

Silva, Grazielle F.; da Silva, Jaqueline S.; de Alencar, Allan K. N.; da Silva, Marina M. C.; Montagnoli, Tadeu L.; Rocha, Bruna S.; de Freitas, Rosana H. C. N.; Sudo, Roberto T.; Fraga, Carlos A. M.; Zapata-Sudo, Gisele. Novel p38 Mitogen-Activated Protein Kinase Inhibitor Reverses Hypoxia-Induced Pulmonary Arterial Hypertension in Rats. Pharmaceuticals, v.15(7), p. 1-16, 2022.

Doi: 10.3390/ph15070900

Silva, Girlaine P.; Fernandes, Daniele C.; Vigliano, Mariana V.; Pinto, Fabiana A.; Fonseca, Eduardo N.; Santos, Shirley V. M.; Marques, Paulo R.; Gayer, Carlos R. M.; Velozo, Leosvaldo S. M.; de Lima, Cleverton K. F.; de Miranda, Ana L. P.; Justo, Maria G.; Sabino, Kátia C. C.; Coelho, Marsen G. P.. Echinodorus macrophyllus: Hydroxycinnamoyl derivatives reduces neutrophil migration through modulation of cytokines, chemokines, and prostaglandin in the air-pouch model. Journal of Ethnopharmacology, v. 284(10), p. 114757, 2022.

Doi: 10.1016/j.jep.2021.114757

da Silva, Jaqueline S.; Gonçalves, Renata G. J.; Vasques, Juliana F.; Rocha, Bruna S.; Nascimento-Carlos, Bianca; Montagnoli, Tadeu L.; Mendez-Otero, Rosália; de Sá, Mauro P. L.; Zapata-Sudo, Gisele.  Mesenchymal Stem Cell Therapy in Diabetic Cardiomyopathy. Cells, v. 11, p. 240, 2022.

Doi: 10.3390/cells11020240

de Souza, Hygor M. R.; Guedes, Jéssica S.; Freitas, Rosana H. C.; Gelves, Luis G. V.; Fokoue, Harold H.;  Sant’Anna, Carlos M. R.; Barreiro, Eliezer J.; Lima, Lídia M.. Comparative chemical and biological hydrolytic stability of homologous esters and isosteres. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 37(1), p. 718-727, 2022.

Doi: 10.1080/14756366.2022.2027933

Valença, Samuel S.; Dong, Brittany E.; Gordon, Elizabeth M.; Sun, Ramon C.; Waters, Christopher M.. ASK1 Regulates Bleomycin-induced Pulmonary Fibrosis. American Journal of Respiratory Cell and Molecular Biology, v. 66, p. 484-496, 2022.

Doi: 10.1165/rcmb.2021-0465OC

Valença, Helber M.; e Silva, Cyntia P.; Gitirana, Lycia B.; Valença, Samuel S.; Lanzetti, Manuella. Beneficial effects of Ilex paraguariensis in the prevention of obesity-associated metabolic disorders in mice. Phytotherapy Research, v. 36, p. 1032-1042, 2022.

Doi: 10.1002/ptr.7377

Viana, Max D. M.; De Lima, Alyne A.; Neto, Geraldo J. S.; Da Silva, Suellen M. A.; Leite, Anderson B.; Dos Santos, Elane C.; Bassi, Ênio J.; Campesatto, Eliane A.; De Queiroz, Aline C.; Barreiro, Eliezer J.; Lima, Lídia M.; Alexandre-Moreira, Magna S.. LASSBio-596: a New Pre-clinical Candidate for Rheumatoid Arthritis?, v. 45, p. 528-543, 2022.

Doi: 10.1007/s10753-021-01564-2

Viana, Elaine O. R.; da Silva, Marília J.; da Silva, Bernadete P.; Tinoc, Luzineide W.; Parente, José P.. Two new triterpenoid saponins from the flowers of Albizia lebbeck. Natural Product Research, p. 1-10, 2022.

Doi: 10.1080/14786419.2022.2031184

Viel, Amanda M.; Figuereido, Célia C. M.; Granero, Filipe O.; Silva, Luciana P.; Ximenes, Valdecir F.; Godoy, Thais M.; Quintas, Luis E. M.; da Silva, Regildo M. G.. Antiglycation, antioxidant and cytotoxicity activities of crude extract of Turnera ulmifolia L. before and after microencapsulation process. Journal of Pharmaceutical and Biomedical Analysis, v. 219, p. 114975, 2022.

Doi: 10.1016/j.jpba.2022.114975

Zapata-Sudo, Gisele.  Riociguate: Uma Alternativa para Tratar a Hipertensão Pulmonar. Arquivos Brasileiros de Cardiologia, v. 119, p. 111-112, 2022.

Doi: 10.36660/abc.20220305

 

2021

Franco, Lucas S. ; Maia, Rodolfo C. ; Barreiro, Eliezer J. Identification of LASSBio-1945 as an inhibitor of SARS-CoV-2 main protease (M PRO ) through in silico screening supported by molecular docking and a fragment-based pharmacophore model. Rsc Medicinal Chemistry, v. 12, p. 110-119, 2021. 

Doi: 10.1039/D0MD00282H

 

Rodrigues, Daniel A. ; Pinheiro, Pedro S. M. ; Fraga, Carlos A. M.  Multitarget Inhibition of Histone Deacetylase (HDAC) and Phosphatidylinositol-3-kinase (PI3K): Current and Future Prospects. ChemMedChem, v. 16, p. 448-457, 2021.

Doi://10.1002/cmdc.202000643

Guerra, Fabiana Sélos ; Rodrigues, Daniel Alencar ; Fraga, Carlos Alberto Manssour ; Fernandes, Patricia Dias . Novel Single Inhibitor of HDAC6/8 and Dual Inhibitor of PI3K/HDAC6 as Potential Alternative Treatments for Prostate Cancer. Pharmaceuticals, v. 14, p. 387, 2021.

Doi://10.3390/ph14050387

Lima, Lidia Moreira; Da Silva, Tiago Fernandes ; Da Silva Monteiro, Carlos Eduardo ; Aparecida-Silva, Cristiane ; Bispo Júnior, Walfrido ; De Queiroz, Aline Cavalcanti ; Alexandre-Moreira, Magna Suzana ; Zapata-Sudo, Gisele ; Barreiro, Eliezer J.  Design and Synthesis In Silico Drug-like Prediction and Pharmacological Evaluation of Cyclopolymethylenic Homologous of LASSBio-1514. Molecules, v. 26, p. 4828, 2021.

Doi://10.3390/molecules26164828

Viana, Max Denisson Maurício ; De Lima, Alyne Almeida ; Da Silva Neto, Geraldo José ; Da Silva, Suellen Maria Albuquerque ; Leite, Anderson Brandão ; Dos Santos, Elane Conceição ; Bassi, Ênio José ; Campesatto, Eliane Aparecida ; De Queiroz, Aline Cavalcanti ; Barreiro, Eliezer Jesus ; Lima, Lidia Moreira ; Alexandre-Moreira, Magna Suzana . LASSBio-596: a New Pre-clinical Candidate for Rheumatoid Arthritis?. Inflammation, v. 25, p. 1, 2021

Doi://10.1007/s10753-021-01564-2

Lorenzoni, Ricardo ; Vidor Contri, Renata ; Kleiton Freitas De Lima, Cleverton ; Barreto, Fabiano ; Verlindo De Araujo, Bibiana ; Raffin Pohlmann, Adriana ; Luísa Palhares De Miranda, Ana ; Dalla Costa, Teresa ; Stanisçuaski Guterres, Silvia . Dermatopharmacokinetic and pharmacodynamic evaluation of a novel nanostructured formulation containing capsaicinoids for treating neuropathic pain. International Journal Of Pharmaceutics, v. 596, p. 120294, 2021.

Doi://10.1016/j.ijpharm.2021.120294

Robba, Chiara ; Battaglini, Denise ; Ball, Lorenzo ; Valbusa, Alberto ; Porto, Italo ; Della Bona, Roberta ; La Malfa, Giovanni ; Patroniti, Nicolò ; Brunetti, Iole ; Loconte, Maurizio ; Bassetti, Matteo ; Giacobbe, Daniele R. ; Vena, Antonio ; Silva, Claudia Lucia M. ; Rocco, Patricia R. M. ; Pelosi, Paolo . Coagulative Disorders in Critically Ill COVID-19 Patients with Acute Distress Respiratory Syndrome: A Critical Review. Journal of Clinical Medicine, v. 10, p. 140, 2021.

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Santana, Marcos V. S. ; Silva-Jr, Floriano P. De novo design and bioactivity prediction of SARS-CoV-2 main protease inhibitors using recurrent neural network-based transfer learning. BMC Chemistry, v. 15, p. 8, 2021.

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Evangelista, Tereza Cristina Santos ; Delarmelina, Maicon ; Addla, Dinesh ; Allão, Rafael A. ; Kaiser, Carlos Roland ; CARNEIRO, JOSÉ WALKIMAR DE M. ; SILVA-JR, FLORIANO PAES ; Ferreira, Sabrina Baptista . Influence of temperature for the azide displacement in benzodiazepine derivatives: Experimental and DFT study of competing SN1, SN2 and double SN2 reaction pathways. Tetrahedron Letters, v. 68, p. 152937, 2021.

Doi: 10.1016/j.tetlet.2021.152937

Cadoná, Francine C. ; Dantas, Rafael Ferreira ; De Mello, Gabriela Haas ; Silva-Jr, Floriano Paes . Natural products targeting into cancer hallmarks: An update on caffeine, theobromine, and (+)-catechin. Critical Reviews In Food Science And Nutrition, v. -, p. 1-20, 2021.

Doi: 10.1080/10408398.2021.1913091

Moreira-Filho, J. T. ; De Souza Neto, Lauro Ribeiro ; Gomes, B.F. ; Dantas, R. F. ; Neves, Bruno J ; Furnham, Nicholas ; Owens, R.J. ; Silva-Junior, Floriano Paes ; Andrade, Carolina Horta . Schistosomiasis Drug Discovery in the Era of Automation and Artificial Intelligence. Frontiers in Immunology, v. 12, p. 1-29, 2021.

Doi:10.3389/fimmu.2021.642383

Gasparotto, Juciano ; Senger, Mario Roberto ; Telles De Sá Moreira, Emilio ; Brum, Pedro Ozorio ; Carazza Kessler, Flávio Gabriel ; Peixoto, Daniel Oppermann ; Panzenhagen, Alana Castro ; Ong, Lin Kooi ; Campos Soares, Marlene ; Reis, Patricia Alves ; Schirato, Giuliana Viegas ; Góes Valente, Walter César ; Araújo Montoya, Bogar Omar ; Silva, Floriano P. ; Fonseca Moreira, José Claudio ; Dal-Pizzol, Felipe ; Castro-Faria-Neto, Hugo C. ; Gelain, Daniel Pens . Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease. Journal Of Biological Chemistry, v. 1, p. 100979, 2021.

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Paes Silva-Jr, Floriano. Combating Neglected Diseases in the Post-COVID-19 World. Revista Virtual De Química, v. 13, p. 308-309, 2021.

Pimentel, Luiz Claudio Ferreira ; Hoelz, Lucas Villas Boas ; Canzian, Henayle Fernandes ; Branco, Frederico Silva Castelo ; De Oliveira, Andressa Paula ; Campos, Vinicius Rangel ; Júnior, Floriano Paes Silva ; Dantas, Rafael Ferreira ; Resende, Jackson Antônio Lamounier Camargos ; Cunha, Anna Claudia ; Boechat, Nubia ; Bastos, Mônica Macedo . (Phenylamino)pyrimidine-1,2,3-triazole derivatives as analogs of imatinib: searching for novel compounds against chronic myeloid leukemia. Beilstein Journal of Organic Chemistry, v. 17, p. 2260-2269, 2021.

Doi: 10.3762/bxiv.2021.44.v1

Valadares, J. M. M. ; Bajaj, S. O. ; Li, H. ; Wang, H. L. ; Silva, S. C. ; Garcia, I. J. P. ; Pereira, D. G. ; Azalim, P. ; Quintas, L. E. M. ; Noël, François ; Cortes, V. F. ; O?Doherty, G. A. ; Barbosa, L. A.  Cytotoxic effect of carbohydrate derivatives of digitoxigenin involves modulation of plasma membrane Ca2+-ATPase. Journal Of Cellular Biochemistry, v. 122, p. 1903-1914, 2021.

Doi: 10.1002/jcb.30150

De Oliveira, Gisele Capanema ; Rocha, Sayonarah Carvalho ; Da Silva Lopes, Miliane Alves ; Paixão, Natasha ; Alves, Silmara Lúcia Grego ; Pessoa, Marco Túlio Corrêa ; Noël, François ; Quintas, Luis Eduardo M. ; Barbosa, Leandro Augusto ; Villar, José Augusto Ferreira Perez ; Cortes, Vanessa Faria . Implications of Synthetic Modifications of the Cardiotonic Steroid Lactone Ring on Cytotoxicity. Journal Of Membrane Biology, v. 1, p. 1, 2021.

Doi: 10.1007/s00232-021-00186-x

 

Pedreira, Júlia Galvez Bulhões ; Silva, Rafaela Ribeiro ; Noël, François G. ; Barreiro, Eliezer J.  Effect of S-Se Bioisosteric Exchange on Affinity and Intrinsic Efficacy of Novel N-acylhydrazone Derivatives at the Adenosine A2A Receptor. Molecules, v. 26, p. 7364, 2021.

Doi: 10.3390/molecules26237364

Noël, F.; Xexéo, G. ; Mangeli, E. ; Mothé, A. ; Marques, P. ; Kritz, J. ; Blanchard, F. ; Vermelho, H. ; Paiva, B. De . Screener, an educational game for teaching the Drug Discovery and Development process. Brazilian Journal of Medical and Biological Research (on line), v. 54, p. e11786, 2021

Doi: 10.1590/1414-431X2021e11786

Acquarone, M. ; Poleto, A. ; Perozzo, A. F. ; Goncalves, P. F. R. ; Panizzutti, R. A. ; Menezes, J. R. L. ; Neves, G.A. ; Barbosa, H. S. Social preference is maintained in mice with impaired startle reflex and glutamate/D-serine imbalance induced by chronic cerebral toxoplasmosis. Scientific Reports, v. 11, p. 14029, 2021.

Doi:  10.1038/s41598-021-93504-1

Da Silva, Jaqueline S. ; Montagnoli, Tadeu L. ; Rocha, Bruna S. ; Tacco, Matheus L. C. A. ; Marinho, Sophia C. P. ; Zapata-Sudo, Gisele . Estrogen Receptors: Therapeutic Perspectives for the Treatment of Cardiac Dysfunction after Myocardial Infarction. International Journal Of Molecular Sciences, v. 22, p. 525, 2021.

Doi: 10.3390/ijms22020525

Alencar, Allan K.N. ; Wang, Hao ; Oliveira, Gláucia M.M. ; Sun, X. ; Zapata-Sudo, Gisele ; Groban, Leanne . Crossroads between Estrogen Loss, Obesity, and Heart Failure with Preserved Ejection Fraction.. Arquivos Brasileiros de Cardiologia (eletronic), v. 00, p. 1, 2021.

Doi: 10.36660/abc.20200855

Vieira, M. C. ; Monte, F. B. M. ; Dematte, B. E. ; Montagnoli, Tadeu L. ; Montes, G. C. ; Da Silva, Jaqueline S. ; Mendez-Otero, Rosália ; Trachez, M.M. ; Sudo, Roberto T. ; Zapata-Sudo, G.  Antinociceptive Effect of Lodenafil Carbonate in Rodent Models of Inflammatory Pain and Spinal Nerve Ligation-Induced Neuropathic Pain. Journal of Pain Research, v. Volume 14, p. 857-866, 2021.

Doi: 10.2147/JPR.S295265

Montagnoli, Tadeu L. ; Da Silva, Jaqueline S. ; Sudo, S. Z. ; Santos, A. D. ; Gomide, G. F. ; Sa, M. P. L. ; Zapata-Sudo, Gisele . ROCK inhibition as potential target for treatment of pulmonary hypertension. Cells, v. 10, p. 1-24, 2021.

Doi: 10.3390/cells10071648

Gubert, F. ; Da Silva J S ; Vasques, Juliana F. ; Goncalves, R. G. J. ; Martins, R. S. ; Sa, M. P. L. ; Mendez-Otero, Rosália ; Zapata-Sudo, G. Mesenchymal Stem Cells Therapies on Fibrotic Heart Diseases. International Journal Of Molecular Sciences, v. 22, p. 7447, 2021.

Doi: 10.3390/ijms22147447

Zanon, Pamela ; Pizzato, Sabrinabeal ; Rosa, Rafaellopesda ; Terraciano, Paulabarros ; Moraes, Joaoalfredo ; Beys-Da-Silva, Walterorlando ; Santi, Luc,Lia ; Yates, Jonhr. ; Passos, Eduardopandolfi ; Barja-Fidalgo, Christina ; Guimaraes, Jorgealmeida ; Berger, Markus . Urine Proteomic Analysis Reveals Alterations In Heme/Hemoglobin And Aminopeptidase Metabolism During Lonomia Obliqua Venom-Induced Acute Kidney Injury. Toxicology Letters, V. 15, P. 1, 2021.

Doi: 10.1016/j.toxlet.2021.01.012

Guimaraes-Bastos, D. ; Frony, A. C. ; Barja-Fidalgo, Christina ; Moraes, J. A.  Melanoma¿Derived Extracellular Vesicles Skew Neutrophils Into A Pro¿Tumor Phenotype. Journal Of Leukocyte Biology, V. 109, P. 10-19, 2021.

DOI: 10.1002/JLB.3A0120-050RR

Link: https://jlb.onlinelibrary.wiley.com/doi/abs/10.1002/JLB.3A0120-050RR

 

Moraes, J. A.; Encarnacao, C. ; Franco, V. A. ; Botelho, L. G. ; Rodrigues, G. P. ; Andrade, I. R. ; Barja-Fidalgo, C. ; Renovato-Martins, Mariana . Adipose Tissue-Derived Extracellular Vesicles And The Tumor Microenvironment: Revisiting The Hallmarks Of Cancer. Cancers, V. 13, P. 1, 2021.

Doi: 10.3390/cancers13133328

Stelling, Mariana Paranhos ; Soares, Mariana Alves ; Cardoso, Simone Coutinho ; Motta, Juliana Maria ; De Abreu, Joice Côrtes ; Antunes, Maria Júlia Mansur ; De Freitas, Vitória Gonçalves ; Moraes, João Alfredo ; Castelo-Branco, Morgana Teixeira Lima ; Pérez, Carlos Alberto ; Pavão, Mauro Sérgio Gonçalves . Manganese Systemic Distribution Is Modulated In Vivo During Tumor Progression And Affects Tumor Cell Migration And Invasion In Vitro. Scientific Reports, V. 11, P. 15833, 2021.

Doi: 10.1038/s41598-021-95190-5

Holanda, G. S. ; Valenca, S. ; Cara, A. M. ; Lichtenberger, R. C. L. ; Castilho, B. ; Franco, O. B. ; Moraes, J. A. ; Schanaider, A. . Translational Application Of Fluorescent Molecular Probes For The Detection Of Reactive Oxygen And Nitrogen Species Associated With Intestinal Reperfusion Injury. Metabolites, V. 11, P. 802, 2021.

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Moraes, J. A.; Rodrigues, G. ; Bastos, D. G. ; Nascimento V ; Svensjo, E. ; Renovato-Martins, M ; Berger, Markus ; Guimarães J.A. ; Barja-Fidalgo, C. Effect Of Lonomia Obliqua Venom On Human Neutrophils. Toxins, V. 13, P. 908, 2021.

Doi: 10.3390/toxins13120908

Silva, José Bruno N. F. ; Calcia, Thayanne B. B. ; Silva, Cyntia P. ; Guilherme, Rafael F. ; Almeida-Souza, Fernando ; Lemos, Felipe S. ; Calabrese, Kátia S. ; Caruso-Neves, Celso ; Neves, Josiane S. ; Benjamim, Claudia F.  Atrvd1 Attenuates Renal Tubulointerstitial Injury Induced By Albumin Overload In Sepsis-Surviving Mice. International Journal Of Molecular Sciences, V. 22, P. 11634, 2021.

Doi: 10.3390/ijms222111634

Borges, Paula Alvarenga ; Waclawiak, Ingrid ; Georgii, Janaína Lima ; Fraga-Junior, Vanderlei Da Silva ; Barros, Janaína Figueiredo ; Lemos, Felipe Simões ; Russo-Abrahão, Thaís ; Saraiva, Elvira Maria ; Takiya, Christina M. ; Coutinho-Silva, Robson ; Penido, Carmen ; Mermelstein, Claudia ; Meyer-Fernandes, José Roberto ; Canto, Fábio B. ; Neves, Josiane Sabbadini ; Melo, Paulo A. ; Canetti, Claudio ; Benjamim, Claudia Farias . Adenosine Diphosphate Improves Wound Healing In Diabetic Mice Through P2Y12 Receptor Activation. Frontiers In Immunology, V. 12, P. 1, 2021.

Doi: 10.3389/fimmu.2021.651740

 

Barroso, Marina Valente ; Gropillo, Isabella ; Detoni, Marcella A. A. ; Thompson-Souza, Glaucia A. ; Muniz, Valdirene S. ; Vasconcelos, Claudia Regina Isaías ; Figueiredo, Rodrigo T. ; Melo, Rossana C. N. ; Neves, Josiane S. . Structural And Signaling Events Driving Aspergillus Fumigatus-Induced Human Eosinophil Extracellular Trap Release. Frontiers In Microbiology, V. 12, P. 1, 2021.

Doi: 10.3389/fmicb.2021.633696

Silva, Juliana Da Costa ; Thompson-Souza, Glaucia De Azevedo ; Barroso, Marina Valente ; Neves, Josiane Sabbadini ; Figueiredo, Rodrigo Tinoco . Neutrophil And Eosinophil DNA Extracellular Trap Formation: Lessons From Pathogenic Fungi. Frontiers In Microbiology, V. 12, P. 1, 2021.

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Mendonca-Reis, E. ; Nobre, C. C. G. ; Paes-Chagas, A. ; Miranda-Alves, L ; Berto-Junior, C. Effects Of Tsh In Erythrocyte Osmotic Fragility: Signalling Pathway. International Journal Of Blood Research And Disorders, V. 7, P. 1-7, 2021.

Doi: 10.23937/2469-5696/1410048

Teixeira, M. P. ; Passos, E. F. ; Haddad, N. F. ; Andrade, M. N. ; Rumjanek, V. M. ; Miranda-Alves, Leandro ; Carvalho, D. P. ; Paiva, L. S. . In Vitro Antitumoral Effects Of The Steroid Ouabain On Human Carcinoma Cell Lines. Environmental Toxicology (Online), V. 36, P. 1338-1348, 2021.

Doi: 10.1002/tox.23130

 

Vasconcellos, M. ; Carra, A. M. ; Franco, O. B. ; Baetas-Da-Cruz, W. ; Ferreira, M. L. ; Silva, P. C. ; Miranda-Alves, L. ; Carvalho, D. P. ; Schanaider, A. . Cryopreserved Rat Thyroid Autotransplantation In The Treatment Of Postoperative Hypothyroidism. Frontiers In Endocrinology, V. 12, P. 625171, 2021.

Doi: 10.3389/fendo.2021.625173

Peixoto, Milena Simões ; De Vasconcelos E Souza, Andressa ; Andrade, Iris Soares ; De Carvalho El Giusbi, Carolina ; Coelho Faria, Caroline ; Hecht, Fabio ; Miranda-Alves, Leandro ; Ferreira, Andrea Claudia Freitas ; Carvalho, Denise Pires ; Fortunato, Rodrigo S . Hypothyroidism Induces Oxidative Stress And Dna Damage In Breast. Endocrine-Related Cancer, V. 28, P. 505-519, 2021.

Doi: 10.1530/ERC-21-0010

Guimaraes-Nobre, C. C. ; Mendonca-Reis, E. ; Costa, L. P. ; Miranda-Alves, Leandro ; Berto-Junior, C. . Signaling Pathway In The Osmotic Resistance Induced By Angiotensin Ii At2 Receptor Activation In Human Erythrocytes. Reports Of Biochemistry And Molecular Biology, V. 10, P. 314-326, 2021.

Doi: 10.52547/rbmb.10.2.314

Zanol, J. F. ; Nino, O. M. ; Costa, C. S. ; Freitas-Lima, L. C. ; Miranda-Alves, L. ; Gracelli, J. B.Tributyltin And High¿Refined Carbohydrate Diet Lead To Metabolic And Reproductive Abnormalities, Exacerbating Premature Ovary Failure Features In The Female Rats. Reproductive Toxicology, V. 103, P. 108-123, 2021.

Doi: 10.1016/j.reprotox.2021.06.004

Romanelli, Mayara A. ; Soeiro, Paula A. ; Costa Da Silva, Raquel ; Taveira-Da-Silva, Rosilane ; Melo, Paulo A. ; Lara, Lucienne S. . Revisiting The Acute Kidney Injury In Wistar Rats Experimentally Envenomated Wity Bothrops Jararacussu Venom.. Toxicon, V. 8, P. S0041-0101(21)00174-4, 2021.

Doi: 10.1016/j.toxicon.2021.06.004

Soeiro, Paula A. ; Romanelli, Mayara A. ; Cesar, Marcelo O. ; Nogueira-Souza, Pâmella D. ; Monteiro-Machado, Marcos ; Oliveira, Simone S.C. ; Santos, André L.S. ; Melo, Paulo A. ; Lara, Lucienne S. Doxycycline Treatment Reestablishes Renal Function Of Wistar Rats In Experimental Envenomation With Bothrops Jararacussu Venom. Toxicon, V. 199, P. 20-30, 2021.

Doi: 10.1016/j.toxicon.2021.05.008

Jannuzzi, Larissa B. ; Pereira-Acacio, Amaury ; Ferreira, Bruna S. N. ; Silva-Pereira, Debora ; Veloso-Santos, João P. M. ; Alves-Bezerra, Danilo S. ; Lopes, Jarlene A. ; Costa-Sarmento, Glória ; Lara, Lucienne S. ; Vieira, Leucio D. ; Abadie-Guedes, Ricardo ; Guedes, Rubem C.A. ; Vieyra, Adalberto ; Muzi-Filho, Humberto . Undernutrition - Thirty Years Of The Regional Basic Diet: The Legacy Of Naíde Teodósio In Different Fields Of Knowledge. Nutritional Neuroscience, V. 19, P. 1-22, 2021.

Doi: 10.1080/1028415X.2021.1915631

Teixeira-Cruz, J. M. ; Strauch, Marcelo A. ; Monteiro-Machado, M. ; Tavares-Henriques, M. ; Moraes, J. A. ; Cunha, L. E. R. ; Ferreira-Junior, Rui S. ; Barraviera, Benedito ; Quintas, Lem Corresponding Author ; Melo, P. A. A Novel Apilic Antivenom To Treat Massive, Africanized Honeybee Attacks: A Preclinical Study From The Lethality To Some Biochemical And Pharmacological Activities Neutralization. Toxins, V. 13, P. 30, 2021.

Doi: 10.3390/toxins13010030

Kinoshita, Paula Fernanda ; Orellana, Ana Maria Marques ; Nakao, Vinicius Watanabe ; Souza Port´S, Natacha Medeiros ; Quintas, Luis Eduardo Menezes ; Kawamoto, Elisa Mitiko ; Scavone, Cristoforo . The Janus Face Of Ouabain In Na+/K+-Atpase And Calcium Signalling In Neurons. British Journal Of Pharmacology, V. 1, P. 1, 2021.

Doi: 10.1111/bph.15419

Oliveira, G. C. ; Rocha, S.C. ; Lopes, M. A. S. ; Paixao, N. ; Alves, S. L. G. ; Pessoa, M. T. C. ; Noël, F. ; Quintas, L. E. M. ; Barbosa, L.A. ; Villar, J.A. ; Cortes, V. F.  Implications Of Synthetic Modiications Of The Cardiotonic Steroid Lactone Ring On Cytotoxicity. Journal Of Membrane Biology, V. 1, P. 1, 2021.

Doi: 10.1007/s00232-021-00186-x

Kawamoto, E. M. ; Cararo-Lopes, M. M. ; Kinoshita, P. F. ; Quintas, L. E. M. ; Lima, L. S. ; Andreotti, D. Z. ; Scavone, C. Influence Of Nitric Oxide-Cyclic Gmp And Oxidative Stress On Amyloid-Β Peptide Induced Decrease Of Na,K-Atpase Activity In Rat Hippocampal Slices. Journal Of Membrane Biology, V. 1, P. 1, 2021.

Doi: 10.1007/s00232-021-00196-9

Valadares, Jéssica Martins De Moura ; Bajaj, Sumit O. ; Li, Hongyan ; Wang, Hua'yu L. ; Silva, Simone Cavalcante ; Garcia, Israel José Pereira ; Pereira, Duane Gischewiski ; Azalim, Pedro ; Quintas, Luis Eduardo Menezes ; Noël, François ; Cortes, Vanessa Faria ; O'doherty, George Augustine ; Barbosa, Leandro Augusto . Cytotoxic Effect Of Carbohydrate Derivatives Of Digitoxigenin Involves Modulation Of Plasma Membrane Ca -Atpase. Journal Of Cellular Biochemistry, V. 1, P. 1, 2021.

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Ferreira Abrao, Camila ; Ribeiro De Oliveira, Danilo ; Passos, Paulo ; Rodrigues Pereira Freitas, Carla Valeria ; Ferreira Santana, Amanda ; Lopes Da Rocha, Marilene ; Ribeiro Da Silva, Antonio Jorge ; Wanderley Tinoco, Luzineide . Zootherapeutic practices in the Amazon Region: chemical and pharmacological studies of Green-anaconda fat (Eunectes murinus) and alternatives for species conservation. Ethnobiology and Conservation, v. 10, p. 1-31, 2021.

Doi: 10.15451/ec2021-02-10.15-1-27

Couto, Jéssyca ; Simas, Daniel ; E Silva, Marcos ; Barth, Thiago ; Pinto, Shaft ; Tinoco, Luzineide ; Freire, Denise ; Muzitano, Michelle ; Leal, Ivana . Hsccc Separations Of Rutin Esters Obtained By Enzymatic Reaction Catalyzed By Lipase. Journal Of The Brazilian Chemical Society, V. 32, P. 523-533, 2021.

Doi: 10.21577/0103-5053.20200206 

Forero, Abel M. ; Castellanos, Leonardo ; Sandoval'hernández, Adrián G. ; Magalhães, Alvicler ; Tinoco, Luzineide W. ; Lopez'vallejo, Fabian ; Ramos, Freddy A.  Integration Of Nmr Studies, Computational Predictions, And Assays In The Search Of Marine Diterpenes With Antitumor Activity. Chemical Biology & Drug Design, V. 00, P. Cbdd.13907-15, 2021.

Doi: 10.1111/cbdd.13907

Costa, Isabela Francisca De Jesus Borges ; Simão, Thatiana Lopes Bia Ventura ; Calixto, Sanderson Dias ; Pereira, Rafaella Velloso ; Konno, Tatiana Ungaretti Paleo ; Pinto, Shaft Corrêa ; Tinoco, Luzineide Wanderley ; Lasunskaia, Elena ; Leal, Ivana Correa Ramos ; Muzitano, Michelle Frazão . Anti-Mycobacterial And Immunomodulatory Activity Of N-Hexane Fraction And Spathulenol From Ocotea Notata Leaves. Rodriguesia, V. 72, P. 2-14, 2021.

Doi: 10.1590/2175-7860202172041

Costa-Filho, R.C. ; Castro-Faria Neto, H. C. ; Mengel, J. ; Pelajo-Machado, M. ; Martins, M. A. ; Leite, E. T. ; Mendonca-Filho, H. T. ; Souza, T. A. C. B. ; Bentacor, G. B. ; Leite, J. P. G.  Should Covid-19 Be Branded To Viral Thrombotic Fever?. Memorias Do Instituto Oswaldo Cruz, V. 116, P. E200552, 2021.

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De Oliveira, Maria Talita Pacheco ; Coutinho, Diego De Sá ; Guterres, Sílvia Stanisçuaski ; Pohlmann, Adriana Raffin ; Silva, Patrícia Machado Rodrigues E ; Martins, Marco Aurélio ; Bernardi, Andressa . Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation And Oxidative Imbalance Induced By Lps In Mice. Pharmaceutics, V. 13, P. 683, 2021.

Doi: 10.3390/pharmaceuthics13050683

Insuela, Daniella Bianchi Reis ; Ferrero, Maximiliano Ruben ; Gonçalves-De-Albuquerque, Cassiano Felippe ; Chaves, Amanda Da Silva ; Da Silva, Adriano Yagho Oliveira ; Castro-Faria-Neto, Hugo Caire ; Simões, Rafael Loureiro ; Barja-Fidalgo, Thereza Christina ; Silva, Patricia Machado Rodrigues E ; Martins, Marco Aurélio ; Silva, Adriana Ribeiro ; Carvalho, Vinicius Frias . Glucagon Reduces Neutrophil Migration And Increases Susceptibility To Sepsis In Diabetic Mice. Frontiers In Immunology, V. 12, P. 633540, 2021.

Doi: 10.3389/fimmu.2021.633540

Ferrero, Maximiliano Ruben ; Garcia, Cristiana Couto ; Dutra De Almeida, Marcella ; Torres Braz Da Silva, Jullian ; Bianchi Reis Insuela, Daniella ; Teixeira Ferreira, Tatiana Paula ; De Sá Coutinho, Diego ; Trindade De Azevedo, Carolina ; Machado Rodrigues E Silva, Patrícia ; Martins, Marco Aurélio . Ccr5 Antagonist Maraviroc Inhibits Acute Exacerbation Of Lung Inflammation Triggered By Influenza Virus In Cigarette Smoke-Exposed Mice. Pharmaceuticals, V. 14, P. 620, 2021.

Doi: 10.3390/ph14070620

Magalhães, Nathalia Santos ; Savino, Wilson ; Silva, Patrícia Machado Rodrigues ; Martins, Marco Aurélio ; Carvalho, Vinicius Frias . Gut Microbiota Dysbiosis Is A Crucial Player For The Poor Outcomes For Covid-19 In Elderly, Diabetic And Hypertensive Patients. Frontiers In Medicine, V. 8, P. 1-11, 2021.

Doi: 10.3389/fmed.2021.644751

Azevedo, C. T. ; Cotias, A. C. ; Arantes, A. C. S. ; Ferreira, T. P. T. ; Martins, M.A. ; Olsen, P.C.  Assessment Of Allergen-Responsive Regulatory T Cells In Experimental Asthma Induced In Different Mouse Strains. Mediators Of Inflammation, V. 2021, P. 1-12, 2021

Doi: 10.1155/2021/7584483

Silveira, Flávia F. ; De Souza, Juliana O. ; Hoelz, Lucas V.B. ; Campos, Vinícius R. ; Jabor, Valquíria A.P. ; Aguiar, Anna C.C. ; Nonato, M. Cristina ; Albuquerque, Magaly G. ; Guido, Rafael V.C. ; Boechat, Nubia ; Pinheiro, Luiz C.S.  Comparative Study Between The Anti-P. Falciparum Activity Of Triazolopyrimidine, Pyrazolopyrimidine And Quinoline Derivatives And The Identification Of New Pfdhodh Inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, V. 209, P. 112941, 2021.

Doi: 10.1016/j.ejmech.2020.112941

Souza, A. A. A. ; Torres, L. R. ; Capobianco, L. R. P. L. ; Paula, V. S. ; Cascabulho, C. M. ; Salomao, K. ; Bonecini-Almeida, M. G. ; Ferreira, Maria De Lourdes G. ; Boechat, N. ; Pinheiro, Luiz C. S. ; Souza, E. M.  Chloroquine And Sulfadoxine Derivatives Inhibit Zikv Replication In Cervical Cells. Viruses-Basel, V. 13, P. 36, 2021.

Doi: 10.3390/v13010036

Sacramento, Carolina Q Fintelman-Rodrigues, Natalia Temerozo, Jairo R Da Silva, Aline De Paula Dias Dias, Suelen Da Silva Gomes Da Silva, Carine Dos Santos Ferreira, André C Mattos, Mayara Pão, Camila R R De Freitas, Caroline S Soares, Vinicius Cardoso Hoelz, Lucas Villas Bôas Fernandes, Tácio Vinício Amorim Branco, Frederico Silva Castelo Bastos, Mônica Macedo Boechat, Núbia Saraiva, Felipe B Ferreira, Marcelo Alves Jockusch, Steffen Wang, Xuanting Tao, Chuanjuan Chien, Minchen Xie, Wei Patel, Dinshaw Garzia, Aitor , Et Al. ; Antiviral Activity Of The Anti-Hcv Drugs Daclatasvir And Sofosbuvir Against Sars-Cov-2, The Aetiological Agent Of Covid-19. Journal Of Antimicrobial Chemotherapy, V. 76, P. 1874-1885, 2021.

Doi: 10.1093/jac/dkab072

Bianco, M. C. A. D. ; Leite, D.I. ; Hoelz, L.V.B. ; Bastos, Monica M. ; Boechat, N.  Pyrroles As Privileged Scaffolds In The Search For New Potential Hiv Inhibitors. Pharmaceuticals, V. 14, P. 893, 2021.

Doi: 10.3390/ph14090893

Coutinho, Julia Penna ; Da Silva Araújo, Maisa ; Campos Aguiar, Anna Caroline ; Sá, Paula Miranda ; Rios, Carlos Tong ; Medeiros, Jansen Fernandes ; Pereira, Dhélio Batista ; Boechat, Nubia ; Krettli, Antoniana Ursine . Mefas, A Hybrid Of Artesunate-Mefloquine Active Against Asexual Stages Of Plasmodium Vivax In Field Isolates, Inhibits Malaria Transmission. International Journal For Parasitology-Drugs And Drug Resistance, V. 17, P. 150-155, 2021.

Doi: 10.1016/j.ijpddr.2021.09.003

França, Rodolfo Rodrigo Florido ; Menozzi, Cheyene Almeida Celestino ; Castelo-Branco, Frederico Silva ; Hoelz, Lucas Villas Bôas ; Boechat, Nubia . The Medicinal Chemistry Of 3-Nitro-1,2,4-Triazoles: Focus On Infectious Diseases. Current Topics In Medicinal Chemistry, V. 21, P. 2072-2100, 2021.

Doi: 10.2174/1568026621999210902124524

 

Dias, Flaviana ; Guerra, Fabiana ; Lima, Fernanda ; De Castro, Yasmin ; Ferreira, Vitor ; Campos, Vinícius ; Fernandes, Patrícia ; Cunha, Anna . Synthesis And Biological Evaluation Of Benzo[F]Indole-4,9-Diones N-Linked To Carbohydrate Chains As New Type Of Antitumor Agents. Journal Of The Brazilian Chemical Society, V. 1, P. 1-14, 2021.

Doi: 10.21577/0103-5053.20200202 

Carvalho, Patricia Ribeiro De ; Sirois, Pierre ; Fernandes, Patricia Dias . The Role Of Kallikrein-Kinin And Renin-Angiotensin Systems In Covid-19 Infection. Peptides, V. 135, P. 170428, 2021.

DOI: 10.1016/j.peptides.2020.170428

Amorim, Jorge Luis ; Lima, Fernanda Alves ; Brand, Ana Laura Macedo ; Cunha, Silvio ; Rezende, Claudia Moraes ; Fernandes, Patricia Dias . Two New Βn-Alkanoyl-5-Hydroxytryptamides With Relevant Antinociceptive Activity. Biomedicines, V. 9, P. 455, 2021.

 

Doi: 10.3390/biomedicines9050455

Guerra, Fabiana Sélos ; Rodrigues, Daniel Alencar ; Fraga, Carlos Alberto Manssour ; Fernandes, Patricia Dias . Novel Single Inhibitor Of Hdac6/8 And Dual Inhibitor Of Pi3k/Hdac6 As Potential Alternative Treatments For Prostate Cancer. Pharmaceuticals, V. 14, P. 387, 2021.

Doi: 10.3390/ph14050387

Giorno, Thais Biondino Sardella ; Lima, Fernanda Alves ; Brand, Ana Laura Macedo ; Oliveira, Camila Martins De ; Rezende, Claudia Moraes ; Fernandes, Patricia Dias . Characterization Of Βn-Octadecanoyl-5-Hydroxytryptamide Anti-Inflammatory Effect. Molecules, V. 26, P. 3709-3722, 2021.

Doi: 10.3390/moléculas26123709

Guerra, Fabiana Sélos ; Dias, Flaviana Rodrigues Fintelman ; Cunha, Anna Claudia ; Fernandes, Patricia Dias . Benzo[F]Indole-4,9-Dione Derivatives Effectively Inhibit The Growth Of Triple-Negative Breast Cancer. Molecules, V. 26, P. 4414, 2021.

Doi: 10.3390/moléculas26154414

Donald, Graciela Rocha ; De Carvalho, Patricia Ribeiro ; Fernandes, Patrícia Dias ; Boylan, Fabio . Antinociceptive Activity Of Puberulin And Choisyine From Ethanol Extract Of Choisya Ternata Kunth Var. Sundance. Biomedicine & Pharmacotherapy, V. 141, P. 111926, 2021.

Doi: 10.1016/j.biopha.2021.111926

 

Insuela, Daniella Bianchi Reis ; Ferrero, Maximiliano Ruben ; Gonçalves-De-Albuquerque, Cassiano Felippe ; Chaves, Amanda Da Silva ; Da Silva, Adriano Yagho Oliveira ; Castro-Faria-Neto, Hugo Caire ; Simões, Rafael Loureiro ; Barja-Fidalgo, Thereza Christina ; Silva, Patricia Machado Rodrigues E ; Martins, Marco Aurélio ; Silva, Adriana Ribeiro ; Carvalho, Vinicius Frias . Glucagon Reduces Neutrophil Migration And Increases Susceptibility To Sepsis In Diabetic Mice. Frontiers In Immunology, V. 12, P. 633540, 2021.

 

Doi: 10.3389/fimmu.2021.633540

Castaño Barrios, Leda ; Da Silva Pinheiro, Ana Paula ; Gibaldi, Daniel ; Silva, Andrea Alice ; Machado Rodrigues E Silva, Patrícia ; Roffê, Ester ; Da Costa Santiago, Helton ; Tostes Gazzinelli, Ricardo ; Mineo, José Roberto ; Silva, Neide Maria ; Lannes-Vieira, Joseli . Behavioral Alterations In Long-Term Toxoplasma Gondii Infection Of C57bl/6 Mice Are Associated With Neuroinflammation And Disruption Of The Blood Brain Barrier. Plos One, V. 16, P. E0258199-30, 2021.

Doi: 10.1371/journal.pone.0258199

Costa, Bianca ; Correa, Luana Barbosa ; Rodrigues E Silva, Patrícia Machado ; Jannini De Sá, Yago Amigo Pinho ; Guimarães, Fernanda Verdini ; Alencar, Luciana Magalhães Rebelo ; Simões, Rafael Loureiro ; Helal-Neto, Edward ; Ricci-Junior, Eduardo ; Muller De Oliveira Henriques, Maria Das Graças ; Rosas, Elaine Cruz ; Santos-Oliveira, Ralph . Using Pure Fucoidan And Radiolabeled Fucoidan (99mtc-Fucoidan) As A New Agent For Inflammation Diagnosis And Therapy. Food Hydrocolloids For Health, V. 1, P. 100049-1, 2021.

 

Doi: 10.1016/j.fhfh.2021.100049

Nascimento, Leandro S. ; Nogueira-Souza, Pâmella D. ; Rocha-Junior, José R.S. ; Monteiro-Machado, Marcos ; Strauch, Marcelo A. ; Prado, Simone A.L. ; Melo, Paulo A. ; Veiga-Junior, Valdir F.  Phytochemical Composition, Antisnake Venom And Antibacterial Activities Of Ethanolic Extract Of Aegiphila Integrifolia (Jacq) Moldenke Leaves. Toxicon, V. 198, P. 121-131, 2021.

Doi: 10.1016/j.toxicon.2021.05.004

Figueiredo-Junior, Alexsandro Tavares ; Dos Anjos, Francisca De Fátima ; Brito, Francisco Das Chagas De Melo ; Viana, Vicente Galber Freitas ; Valença, Samuel Santos ; Lanzetti, Manuella ; Finotelli, Priscilla Vanessa . Bixin Loaded On Polymeric Nanoparticles: Synthesis, Characterization, And Antioxidant Applications In A Biological System. Applied Nanoscience, V. 11, P. 63-78, 2021.

 

Doi: 10.1007/s13204-020-01555-z

Sampaio De Holanda, Gustavo ; Dos Santos Valença, Samuel ; Maran Carra, Amabile ; Lopes Lichtenberger, Renata Cristina ; Franco, Olavo Borges ; Ribeiro, Beatriz Elias ; Bittencourt Rosas, Siane Lopes ; Santana, Patricia Teixeira ; Lima Castelo-Branco, Morgana Teixeira ; Pereira De Souza, Heitor Siffert ; Schanaider, Alberto . Sulforaphane And Albumin Attenuate Experimental Intestinal Ischemia-Reperfusion Injury. Journal Of Surgical Research, V. 262, P. 212-223, 2021.

DOI: 10.1016/j.jss.2021.01.014

Cardoso, Aline De Oliveira Pontes ; Pecli E Silva, Cyntia ; Dos Anjos, Francisca De Fátima ; Quesnot, Nicolas ; Valenca, Helber Da Maia ; Cattani-Cavalieri, Isabella ; Brito-Gitirana, Lycia ; Valenca, Samuel Santos ; Lanzetti, Manuella . Diallyl Disulfide Prevents Cigarette Smoke-Induced Emphysema In Mice. Pulmonary Pharmacology & Therapeutics, V. 69, P. 102053, 2021.

DOI: 10.1016/j.pupt.2021.102053

Scientific Publications

2021

Lorenzoni, R.; Contri, R.V.; Lima, C. K. F.; Barreto, F. ; Araujo, B. V.; Pohlmann, A.R. ;  Miranda, A.L.P. ; Costa, T.D. ; Guterres, S.S . Dermatopharmacokinetic and pharmacodynamic evaluation of a novel nanostructured formulation containing capsaicinoids for treating neuropathic pain. International Journal of Pharmaceutics, v. 596, p. 120294, 2021.

Doi: 10.1016/j.ijpharm.2021.120294


Robba, C.; Battaglini, D. ; Ball, L.; Valbusa, A. ; Porto, I. ; Bona, R.D.; Malfa, G. ; Patroniti, N. ; Brunetti, I. ; Loconte, M. ; Bassetti, M. ; Giacobbe, D. R. ; Vena, Antonio ; Silva, C.L. M. ; Rocco, P. R. M. ; Pelosi, P.  Coagulative Disorders in Critically Ill COVID-19 Patients with Acute Distress Respiratory Syndrome: A Critical Review. Journal of Clinical Medicine, v. 10, p. 140, 2021.

 

Doi: 10.3390/jcm10010140

Santana, M. V. S. ; Silva, F. P. . De novo design and bioactivity prediction of SARS-CoV-2 main protease inhibitors using recurrent neural network-based transfer learning. BMC Chemistry, v. 15, p. 8, 2021.

Doi:10.1186/s13065-021-00737-2

Silva, J. S. ; Montagnoli, T. L. ; Rocha, B. S. ; Tacco, M. L. C. A. ; Marinho, S. C. P. ;  Sudo, G.Z . Estrogen Receptors: Therapeutic Perspectives for the Treatment of Cardiac Dysfunction after Myocardial Infarction. International Journal of Molecular Sciences, v. 22, p. 525, 2021.

 

Doi:10.3390/ijms22020525

Alencar, A. K.N. ; Wang, H. ; Oliveira, G. M.M. ; Sun, X. ;  Sudo, G.Z. ; Groban, L. Crossroads between Estrogen Loss, Obesity, and Heart Failure with Preserved Ejection Fraction.. Arquivos Brasileiros de Cardiologia (eletronic), v. 00, p. 1, 2021.

 

Silva, J. ; Thompson'souza, G. A. ; Barroso, Marina Valente ; Neves, J. S. ; Figueiredo, R. T. Neutrophil and eosinophil DNA extracellular trap formation: lessons from pathogenic fungi. Frontiers in Microbiology, 2021.

 

Doi: 10.3389/fmicb.2021.634043

Barroso, M.V. ; Gropillo, I. ; Detoni, M. ; Thompson'souza, G. A. ; Vasconcelos, C. I. ; Muniz, V. S. ; Figueiredo, R. T. ; Melo, R. C N ; Neves, J. S.Signaling events driving Aspergillus fumigatus-induced human eosinophils extracellular trap release. Frontiers in Microbiology, 2021.

 

Couto, J.; Simas, D. ; Silva, M. ; Barth, T. ; Pinto, S.; Tinoco, L.W. ; Freire, D.; Muzitano, M. ; Leal, I.. HSCCC Separations of Rutin Esters Obtained by Enzymatic Reaction Catalyzed by Lipase. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY , v. 000, p. 000, 2021.

 

Doi: 10.21577/0103-5053.20200206 


Silveira, F. F.; Souza, J. O.; Hoelz, L. V.B. ; Campos, V. R. ; Jabor, V. A.P. ; Aguiar, A. C.C. ; Nonato, M. C. ; Albuquerque, M. G. ; Guido, R. V.C. ; Boechat, N. ; Pinheiro, L.C.S.  Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors. European Journal of Medicinal Chemistry, v. 209, p. 112941, 2021.

 

 

Doi:10.1016/j.ejmech.2020.112941

Dias, F.; Guerra, F.; Lima, F. ; Castro, Y. ; Ferreira, V. ; Campos, V. ; Fernandes, P. ; Cunha, A. Synthesis and Biological Evaluation of Benzo[f]indole-4,9-diones N-Linked to Carbohydrate Chains as New Type of Antitumor Agents. Journal of the Brazilian Chemical Society, v. 1, p. 1-14, 2021.

 

Doi.org/10.21577/0103-5053.20200202.

Carvalho, P.R.; Sirois, P.; Fernandes, P.D.  The role of kallikrein-kinin and renin-angiotensin systems in COVID-19 infection. Peptides, v. 135, p. 170428, 2021.

 

Doi.org/10.1016/j.peptides.2020.170428

Junior, A.T.F.; Anjos, F.F.; Brito, F. C. M. ; Viana, V.G.F. ; Valença, S.S. ; Lanzetti, M. ; Finotelli, P.V. Bixin loaded on polymeric nanoparticles: synthesis, characterization, and antioxidant applications in a biological system. Applied Nanoscience, v. 11, p. 63-78, 2021.

 

Doi: 10.1007/s13204-020-01555-z

2020

Silva, N. L. C.; Mota, N. A. V. ; Soares, M. A. ; Araujo, O.M.O.; Espindola, L. C. P. ; Colombo, A. P. V. ; Lopes, R. T. ; Brito, F.C. F. ; Miranda, A. L. P. ; Tributino, J.L.M . Periodontal status, vascular reactivity, and platelet aggregation changes in rats submittedto hypercholesterolemic diet and periodontitis. Journal of periodontal research, v. 55, p. 453-463, 2020.

 

Doi: 10.1111/jre.12730

 

 

Rodrigues, D. A.; Pinheiro, P.S.M. ; Sagrillo, F.S. ; Freitas, M.C.R. ; Alves, M.A, ; Thota, S. ; Tinoco, L.W. ; Magalhães, A. ; Sant'anna, C. ; Fraga, C.A.M . Structure-Property Relationship Studies of 3-Acyl-Substituted Furans: The Serendipitous Identification and Characterization of a New Non-Classical Hydrogen Bond Donor Moiety. New Journal of Chemistry, v. 44, p. 10994-11005, 2020.

 

Doi.org/10.1039/D0NJ01598A

 

 

Rodrigues, D. A ; Pinheiro, P. S. M. ; Sagrillo, F. S. ; Bolognesi, M. L. ; FRAGA, C. A. M. Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities. Medicinal Research Reviews, v. 40, p. 2177-2211, 2020.

 

Doi: 10.1002/med.21701

 

Cunha, T.T.S.; Souza, F. R.; Pinheiro, P. S.M.; Sant’anna, C. M.R.; NOËL, F.; França, T.C. C.; Fraga, C.A.M. Investigating the Molecular Basis for the Selective Inhibition of Aldehyde Dehydrogenase 2 by the Isoflavonoid Daidzin. CNS & Neurological Disorders-Drug Targets, v. 19, p. 437-447, 2020.

 

Doi: 10.2174/1871527319999200817153150

 

Viegas, C. ; Fraga, C. A. M.; Sousa, M. E. ; Tarozzi, A . Editorial: Oxidative Stress: How Has It Been Considered in the Design of New Drug Candidates for Neurodegenerative Diseases?. Frontiers in Pharmacology, v. 11, p. 609274, 2020.

 

Doi:10.3389/fphar.2020.609274

Thorstenberg, M. L. ; Martins, M. D. A. ; Figliuolo, V. ; Silva, C.L. M ; Savio, L.E. ; Silva, R.C . P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1β Secretion. Mediators of Inflammation, v. 2020, p. 1-11, 2020.

 

Doi: 10.1155/2020/2545682

Oliveira, N.F.; Silva, C.L.M. Unveiling the potential of purinergic signaling in schistosomiasis treatment. Current Topics in Medicinal Chemistry, v. 20, p. 1, 2020.

Doi: 10.2174/1568026620666200924115113

 

Teixeira, R. G. S.; Pascual, R.; Araújo, K.G.L.; Brito, M. A. ; RIOS, C. ; C., A. F. ; Gandía, L. ; Silva, C. L. M. ; Machado, T. B. ; Santos, Wilson,C. In vitro and in silico studies for barbinervic acid, a triterpene isolated from Eugenia punicifolia that inhibits vasopressor tone. Natural Product Research. V. 1, p. 1-6, 2020.

Doi: 10.1080/14786419.2020.1739675

 

Pauli, F. P.; Martins, J. R.; Paschoalin, T. ; Ionta, M. ; Barbosa, M. L. C. ; Barreiro, E. J.  Novel VEGFR-2 inhibitors with an N -acylhydrazone scaffold. Archiv Der Pharmazie, v. 276, p. e2000130., 2020.

 

Alves, M. A.;Queiroz, A. C. ; Leite, A. B. ; Martins, F.T. ; Doriguetto, A. C. ; Barreiro, E. J. ; Moreira, M. S. A. ; Lima, L. M.  Carbamoyl- N -aryl-imine-urea: a new framework to obtain a putative leishmanicidal drug-candidate. RSC Advances, v. 10, p. 12384-12394, 2020.

 

Pedreira, J. G. B.; Nahidino, P.; Kudolo, M.; Pantsar, T.; Berger,B.T. ; Forster, M. ; Knapp, S.; Laufer, S. ; Barreiro, E. J.  Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors. Journal Of Medicinal Chemistry, v. 63, p. 7347-7354, 2020.

Doi:10.1021/acs.jmedchem.0c00508

 

Colodette, N. M.; Franco, L. S.; Maia, Rodolfo C.; Fokoue, H. H.; Sant’anna, C. M. R.; Barreiro, E. J.  Novel phosphatidylinositol 4-kinases III beta (PI4KIIIβ)  inhibitors discovered by virtual screening using free energy models. Journal Of Computer-aided Molecular Design, v. 34, p. 1091-1103, 2020.

Doi:10.1007/s10822-020-00327-9

 

Lima, L. M. ; Silva, B. N. M.; Barbosa, G. ; Barreiro, E. J. β-lactam antibiotics: An overview from a medicinal chemistry perspective. European Journal Of Medicinal Chemistry, v. 208, p. 112829, 2020.

Doi:10.1016/j.ejmech.2020.112829

Senger, M. R. ; Evangelista, T. C. S. ; Dantas, R. F. ; Santana, M. V. S. ; Gonçalves, L. C. S.; Neto, L. R.S. ; Ferreira, S. B. ; Junior, F. P.S . COVID-19: molecular targets, drug repurposing and new avenues for drug discovery. Memórias do Instituto Oswaldo Cruz, v. 115, p. 1, 2020.

Doi.org/10.1590/0074-02760200254 


Neto, L.R.S.; Filho, J.T.M. ; Neves, B.J. ; Maidana, R.L.B.R. ; Guimarães, A.C.R. ; Furnham, N. ; Andrade, C.H. ; Silva, F.P . In silico strategies to support fragment-to-lead optimization in drug discovery. Frontiers in Chemistry, v. 8, p. 1-18, 2020.

 

Doi.org/10.3389/fchem.2020.00093

Issy A.C.; Pedrazzi, J. F. C.; Van Oosten, A. B. S.; Checheto, T.; Silva, R. R.; Noel, F.; Del-bel, E.  Effects of doxycycline in Swiss mice predictive models of schizophrenia. Neurotoxicity Research, v. 101007, p. s1264002000268z, 2020.

 

Doi: 10.1007/s12640-020-00268-z

Silva, M. M. C.; Alencar, Nogueira, A.K.; Silva, J.S.; Montagnoli, T.L.; Silva, G.F.; Rocha, B.S.; Montes, G.C.; Otero, R.M.; Coelho, P.M.P.; Vasques, J. F.; Trahez, M.M.; Sudo, R.T.; Sudo, G.Z. Therapeutic Benefit of the Association of Lodenafil with Mesenchymal Stem Cells on Hypoxia-induced Pulmonary Hypertension in Rats. Cells, v. 9, p. 2120, 2020.

 

Doi: 10.3390/cells9092120.

Borsoi, M. ; Nunes, L. E. D. ; Barbosa, A. R. ; Lima, M. S. ; Medeiros, I. ; Pranke, M. A. ; Antonio, C. B. ; RATES, S. M. K. ; Neves, G.A.  Intermittent repeated stress but not ketamine changes mice response to antidepressants. Neuroscience Letters, p. 135452, 2020.

 

Doi: 10.1016/j.neulet.2020.135452

Silva, J. C.; Rodrigues, N. C.; Thompson'souza, G. A.; Muniz, V. S.; Neves, J. S.; Figueiredo, R. T.  Mac-1 triggers neutrophil DNA extracellular trap formation to Aspergillus fumigatus independently of PAD4 histone citrullination. Journal of Leukocyte Biology, v. 107, p. 69-83, 2020. 

Doi: 10.1002/JLB.4A0119-009RR

 

Nino, O. M.; Costa, C. S.; Torres, K. M.; Zanol, J. F.; Lima, L. C. F.; Alves, L.M.; Graceli, J. B. High refined carbohydrate diet leads to polycystic ovary syndrome-like features and reduced ovarian reserve in female rats. Toxicology Letters, v. 332, p. 42-55, 2020.

Doi.org/10.1016/j.toxlet.2020.07.002

 

Graceli, J. B.; Dettogni, R. S.; Merlo, E.; Nino, O. M.; Costa, C. S.; Zanol, J. F.; Morris, E. A. R. ; Alves, L.M. ; Denicol, A. C.  The impact of endocrine-disrupting chemical exposure in the mammalian hypothalamic-pituitary axis. Molecular and Cellular Endocrinology, v. 518, p. 110997-111017, 2020.

Doi.org/10.1016/j.mce.2020.110997

 

Junior, N. C.L.; Camilo, J. F.; Carmo, P. R.; Andrade, M. N.; Braz, B. F.; Santelli, R. E.; Gitirana, L. B.; Ferreira, A. C. F. ; Carvalho, D. P. ; Alves, L.M. ; Dias, G. R. M.  Subacute Exposure to Lead Promotes Disruption in the Thyroid Gland Function in Male and Female Rats. Environmental Pollution, 2020.

 

Doi:10.1016/j.envpol.2020.115889

Chagas, A.P.; Peixoto, B.P.; Costa, B.B.; Moreira, T.A.; Cinelli, L.P.; Silva, L.L.; Alves, L.M.; Junior, C.B. Effects of Bisphenol A and S on blood coagulation: in vivo, in vitro and in silico approaches in toxicodynamic. Toxicology Mechanisms and Methods, v. 31, p. 1-34, 2020.
 

Doi:10.1080/15376516.2020.1836102

Almeida, J.; Oliveira, V.R.; Avelar, J.L.S.; Moita, B.S.; Lima, L.M. COVID-19: Physiopathology and Targets for Therapeutic Intervention. Revista Virtual de Química, v. 12, p. 0000, 2020.

Curnow, A. C.; Gonsalez, S. R.; Gogulamudi, V. R.; Visniauskas, B. ; Simon, E. E. ; Gonzalez, A. A. ; Majid, D. S. A. ; Lara, L.S. ; Prieto, M. C.  Low Nitric Oxide Bioavailability Increases Renin Production in the Collecting Duct. Frontiers in Physiology, v. 11, p. 153, 2020.

 

Doi.org/10.3389/fphys.2020.559341

 

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